MYO3A

MYO3A

A gene on chromosome 10p11.1 that encodes an actin-based molecular motor with ATPase activity, which belongs to the unconventional myosin protein family. As with the other Class-III myosins, MYO3A is highly expressed in the cochlea and in retinal photoreceptors.

Molecular pathology
Loss of function mutations of MYO3A cause progressive non-syndromic hearing loss.
References in periodicals archive ?
CISD2 3 1 1 0 OTOGL 58 0 34 0 Watch list: low GC-can be problematic MYO6 34 0 27 0 Watch list: low GC-can be problematic GPR98 90 0 24 0 Watch list: low GC-can be problematic MYO3A 33 0 18 0 Watch list: low GC-can be problematic HSD17B4 26 0 13 0 Watch list: low GC-can be problematic PCDH15 39 0 12 0 Watch list: low GC-can be problematic RDX 14 0 10 0 Watch list: low GC-can be problematic SERPINB6 9 0 1 1 Watch list: high GC-can be problematic GIPC3 6 0 0 1 Watch list: high GC-can be problematic KCNQ1 17 0 0 1 Watch list: high GC-can be problematic P2RX2 10 0 0 1 Watch list: high GC-can be problematic TMIE 4 0 0 1 Watch list: high GC-can be problematic Table 3.
Ilk gruptaki MYO3A, CA10, NKX6-2 ve DBC1 veya SOX11'in mesane kanserini saptamadaki duyarliligi %81 ve ozgullugu %97 iken MYO3A, CA10, NKX6-2 ve DBC1 veya PENK iceren ikinci grupta duyarliligi %85, ozgullugu %95 olarak bulunmustur.