MYO18B

MYO18B

A gene on chromosome 22q12.1 that encodes an actin- and ATP-binding motor protein, which is thought to be involved in intracellular trafficking when located in the cytoplasm, and regulation of muscle specific genes once in the nucleus.

Molecular pathology
MYO18B may play a role in controlling tumour development and progression; restoration of MYO18B expression in lung cancer cells suppresses anchorage-independent growth.
References in periodicals archive ?
The MYO18B is known to be a tumor-suppressor gene and mutations in this gene are associated with lung cancer (Nishioka et al.
Genetic and epigenetic alterations of the candidate tumor-suppressor gene MYO18B, on chromosome arm 22q, in colorectal cancer.
MYO18B, a candidate tumor suppressor gene at chromosome 22q12.
Correlation between histone acetylation and expression of the MYO18B gene in human lung cancer cells.
Reduced expression of MYO18B, a candidate tumor-suppressor gene on chromosome arm 22q, in ovarian cancer.
To define the molecular network of lung carcinogenesis, systematic analysis of mRNA and protein expression levels of thousands of genes have been accomplished and among them, p53 and RB/p16 defective pathways and expression of several genes such as K-ras, PTEN, FHIT, and MYO18B, have been demonstrated to be altered (109).