MUC6

MUC6

A gene on chromosome 11p15.5 which encodes gastric mucin, a secreted glycoprotein that plays an essential role in epithelial cytoprotection from acid, proteases, pathogenic microorganisms and mechanical trauma in the gastrointestinal tract. MUC6 may help modulate the composition of the protective mucus layer related to acid secretion or the presence of bacteria and noxious agents in the lumen, and play a role in the cytoprotection of epithelial surfaces and in epithelial organogenesis.

Molecular pathology
MUC6 has shown promise as a tumour marker.
References in periodicals archive ?
MUC5AC and MUC6 are markers of gastric foveolar cells and antral/cardiac mucous glandular cells, respectively, and they reflect gastric phenotypes.
MUC6 down-regulation correlates with gastric carcinoma progression and a poor prognosis: an immunohistochemical study with tissue microarrays.
In: Proceedings of the MUC6, Morgan-Kauffman Publisher (1995)
Expression of MUC1, MUC2, MUC5AC, and MUC6 in atypical adenomatous hyperplasia, bronchioloalveolar carcinoma, adenocarcinoma with mixed subtypes, and mucinous bronchioloalveolar carcinoma of the lung.
If the percentage of cells revealing cytoplasmic (MUC2, MUC5AC, MUC6, CK7, CK20), membranous (E-cadherin), apical membranous or cytoplasmic (MUC1), and nuclear (CDX2, MLH 1, MSH 2) labeling were greater than 10% of the cells, that slide was regarded as positive, as has been done in other studies.
2, CK [cytokeratin] 7, CK20, CK17, CK19, MUC1, MUC2, MUC4, MUC5AC, MUC6, p53, DPC4/ SMAD4, CDX2, pVHL [von Hippel-Lindau tumor suppressor gene protein], S100P, IMP-3 [insulin-like growth factor 2 messenger RNA binding protein 3], maspin, mesothelin, claudin 4, claudin 18, annexin A8, fascin, PSCA [prostate stem cell antigen], MOC31, CEA [carcinoembryonic antigen], and CA19-9 [cancer antigen 19-9]) in the diagnosis of ductal adenocarcinoma of the pancreas by using 60 cases of pancreatic DAC on routine and tissue microarray (TMA) sections.
35-38) For example, MUC1 and MUC6 have been demonstrated by some observers to be expressed in BE but not in cardiac IM.
MUC6 stain was positive in small, pyloric, gland-like ductular structures embedded in the fibrous stroma (Figure 4, B).
35) The markers that show the most promise are MUC1 and MUC6, which seem to distinguish between esophageal and cardiac intestinal metaplasia in most cases, although more studies are needed to validate these results.
101) Immunolabeling-based studies have reported overexpression of CTNNB1, (100) INHA, MUC6, ENO2, MUC1, (102) ANXA1, (103) CA9, (104) and SPARCL1 (105) in some of these less common exocrine neoplasms.
The pattern does appear to be full recapitulation of gastric mucosa, with small glandular elements at the base that express MUC6 mucin and more papillary areas expressing MUC5AC.
Thirty-eight gastric biopsies diagnosed as reactive gastropathy, related to nonsteroidal anti-inflammatory drugs (n = 18) or bile reflux (n = 6) or of indeterminate etiology (n = 14), were evaluated using antibodies to MUC1, MUC5AC, MUC6, and MUC2.