MUC6

MUC6

A gene on chromosome 11p15.5 which encodes gastric mucin, a secreted glycoprotein that plays an essential role in epithelial cytoprotection from acid, proteases, pathogenic microorganisms and mechanical trauma in the gastrointestinal tract. MUC6 may help modulate the composition of the protective mucus layer related to acid secretion or the presence of bacteria and noxious agents in the lumen, and play a role in the cytoprotection of epithelial surfaces and in epithelial organogenesis.

Molecular pathology
MUC6 has shown promise as a tumour marker.
References in periodicals archive ?
They are often positive for MUC5AC (90%, 55 of 61) and MUC6 (74%, 29 of 39), and mostly negative for MUC2 (only 8%, 5 of 61 with focal staining; Table 4).
pylori-positive patients exhibited an increase in MUC6 in surface mucous cells with a reduction in MUC5AC," stated the researcher in his paper.
In cases with ovarian tumours, immunostaining for cytokeratin 7, MUC2, MUC5AC, and MUC6 has been reported to be useful in distinguishing from metastatic tumors.
Varios genes que expressam mucinas, como MUC2, MUC5AC, MUC5B e MUC6, ja tem sido descritos, sendo o MUC5AC e MUC6 os mais presentes na superficie gastrica de humanos (HO SB et al.
En el hombre, los genes que codifican para las mucinas estan programados para configurar 19 familias divididas en dos grupos: el primero son las mucinas ancladas a la membrana, siendo las mas importantes las mucinas MUC1, MUC3, MUC4; el segundo grupo son las mucinas secretadas, siendo las principales las mucinas MUC2, MUC5AC, MUC5B y MUC6.
MUC6 down-regulation correlates with gastric carcinoma progression and a poor prognosis: an immunohistochemical study with tissue microarrays.
In: Proceedings of the MUC6, Morgan-Kauffman Publisher (1995)
5) The four major secreted gel-forming mucins are MUC5AC (stomach (14) and airways (15)), MUC5B (airways (16) and gallbladder (17)), MUC2 (colon (18)) and MUC6 (stomach (19)), the genes of which are clustered on chromosome 11.
Advances in information extraction from text have been well documented in a series of rigorous performance evaluations sponsored by the Defense Advanced Research Projects Agency called the message-understanding conferences (MUC) (MUC3 1991; MUC4 1992; MUC5 1993; MUC6 1995).
Expression of MUC1, MUC2, MUC5AC and MUC6 in cholangiocarcinoma: prognostic impact.
check] -ve -ve S1 [check] -ve -ve S4 [check] +ve (2+) +ve (2+) S5 [check] -ve -ve (< 5%) S6 [check] -ve -ve S7 [check] -ve +ve (1+) S8 [check] -ve -ve Laboratory number MUC2 MUC5AC MUC5B MUC6 C1 +ve (3+) -ve +ve (4+) -ve C2 +ve (3+) -ve +ve (4+) -ve C3 +ve (3+) -ve +ve (2+) -ve C4?
21) MUC6 is a component of mucin that is found in gastric pyloric glands.