MUC5AC


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MUC5AC

A gene on chromosome 11p15.5 that encodes a gel-forming glycoprotein of gastric and respiratory tract epithelia, which protects the mucosa from infection and chemical damage by binding to inhaled microorganisms and particles, which are subsequently removed by the mucocilary system.

Molecular pathology
MUC5A stains are positive in foveolar dysplasia.
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Two key markers of the beta arrestin pathway - ERK1 and MUC5AC - which are necessary for the activation of mucous metaplasia in the airway, showed the most robust changes.
To understand patients' eye strain, which is one of major symptoms of dry eye disease, it is important that ophthalmologist pay attention to MUC5AC concentration in tears," said Dr.
6% (85 of 412) were positive for MUC5AC, MUC6, MUC2, and CD10, respectively (Figure 2, A through D).
In the eight patients who served as controls, MUC5AC expression was reduced in two, compared with baseline values.
Expression of MUC1, MUC2, MUC5AC, and MUC6 in atypical adenomatous hyperplasia, bronchioloalveolar carcinoma, adenocarcinoma with mixed subtypes, and mucinous bronchioloalveolar carcinoma of the lung.
The NPC-1C epitope appears to be a variant of MUC5AC that is expressed specifically by human colon and pancreatic tumor tissues and cell lines with only minimal and weak cross-reaction occasionally to certain GI tract tissues.
Therefore, in this study, we checked whether ophiopogonin D and spicatoside A affect MUC5AC mucin production and secretion from NCI-H292 cells, a human pulmonary mucoepidermoid cell line, which are frequently used for the purpose of studying the airway mucin production (Li et al.
Clca3 has been implicated in the regulation of mucus secretion by controlling the packaging and/or release of secreted mucins such as MUC5AC and MUC5B, which are the major gel-forming mucins in respiratory secretions (Nakanishi et al.
219) showed that pretreatment with solithromycin, along with azithromycin and telithromycin, inhibited SMM-induced expression of mRNA of inflammatory genes, particularly MUC5B (mucin-5B) and MUC5AC (mucin-5AC).