MUC5AC


Also found in: Dictionary.

MUC5AC

A gene on chromosome 11p15.5 that encodes a gel-forming glycoprotein of gastric and respiratory tract epithelia, which protects the mucosa from infection and chemical damage by binding to inhaled microorganisms and particles, which are subsequently removed by the mucocilary system.

Molecular pathology
MUC5A stains are positive in foveolar dysplasia.
Mentioned in ?
References in periodicals archive ?
of Cases Cytokeratin 7 39(100) 39 MUC5AC 55 (90) 61 MUC1 11 (35) 31 MUC2 5 (focal, 8) 61 MUC6 29 (74) 39
The expression of MUC5AC and MUC5B mucin genes in the mucosa of chronic rhinosinusitis and nasal polyposis.
pylori] inhibits the expression of SOX2 in gastric epithelial cells, hence activating transcription factor CDX2 as a counterpart to MUC5AC gene inhibition andMUC2 gene induction," elaborated Dr.
MUC5AC is the principal mucin produced by goblet cells, and MUC5B is produced by submucosal glands (18).
The MUC5AC glycoprotein is the primary receptor for Helicobacter pylori in the human stomach.
The goblet cells of the conjunctiva secrete a soluble, gel-forming mucin known as MUC5AC.
But study participants with the most screen time had MUC5AC levels nearing those of people with diagnosed dry eye.
Varios genes que expressam mucinas, como MUC2, MUC5AC, MUC5B e MUC6, ja tem sido descritos, sendo o MUC5AC e MUC6 os mais presentes na superficie gastrica de humanos (HO SB et al.
Interestingly, the GALNAC-T8, -T9, and -T18 enzymes do not have catalytic activity toward classic peptide substrates, which are derived from mucin 1 (MUC1) variant MUC1/A, MUC5AC, and mono-GalNAc/Thr7th-EA2 (a glycopeptide containing 1 GalNAc in the threonine at the 7th position, named EA2) (31), suggesting that the GALNAC-T members of this subfamily may glycosylate very specific substrates.
Kaempferol and quercetin, essential ingredients in Ginkgo biloba extract, inhibit interleukin-1 beta-induced MUC5AC gene expression in human airway epithelial cells.
15) Mucin staining for MUC1 and MUC5AC are both positive in pancreatic adenocarcinomas, as are CK7 and CK20.