MUC4

MUC4

A gene on chromosome 3q29 that encodes an integral membrane glycoprotein found on cell surfaces, which may play a role in tumour progression by repressing apoptosis. MUC4 may alter cellular behaviour through both its anti-adhesive effects on cell-cell and cell-extracellular matrix interactions and its ability to act as a ligand for ERBB2, the phosphorylation of which plays an important role in epithelial cell proliferation and differentiation.
References in periodicals archive ?
The lesional cells were diffusely positive for MUC4, thus resulting in a diagnosis of low-grade fibromyxoid sarcoma (Figure 9, A through C).
Expression of membrane-associated mucins MUC1 and MUC4 in major human salivary glands.
Experimental studies indicate that tumour overexpression of MUC4 and also CD44 may be further elements that interfere with adequate binding of trastuzumab to its target receptor sites to promote resistance [19].
There are a whole host of trans-membrane mucins, from which I have chosen MUC1 and MUC4 for this presentation.
Expression of mucins (MUC1, MUC2, MUC3, MUC4, MUC5AC and MUC6) and their prognostic significance in human breast cancer.
ABSTRACT : In 2004, Jorgensen and coworkers proposed the MUC4 gene as a candidate gene of enterotoxigenic Escherichia coli (ETEC) F4ab/ac receptor in piglets and a mutation of G [right arrow] C in intron 7 of MUC4 was identified to be associated with the ETEC F4ab/ac adhesion phenotypes.
Examples of potentially relevant mechanisms include: disruption of the trastuzumab-HER2 interaction which has been demonstrated, for example, to occur by the overexpression of MUC4, a sialomucin complex overexpressed in some breast tumours [49,50]; increased signalling through other members of the HER family, such as HER1, to downstream messenger pathways [51,52]; compensatory signalling through other receptor types such as insulin-like growth factor-I receptor (IGF-IR) which is able to inhibit HER2 sensitivity to trastuzumab through crosstalk [53,54]; or modulation of downstream signalling pathways for example via PTEN deficiency [14] or downregulation of p27(Kip1) [55].
Advances in information extraction from text have been well documented in a series of rigorous performance evaluations sponsored by the Defense Advanced Research Projects Agency called the message-understanding conferences (MUC) (MUC3 1991; MUC4 1992; MUC5 1993; MUC6 1995).
Mammary analogue secretory carcinoma may also express GATA3, pancytokeratin, CK7, CK8, CK18, CK19, epithelial membrane antigen, vimentin, MUC1, MUC4, STAT5a, GCDFP15, and adipophilin, (3,17) but these are typically not used clinically in the diagnosis of MASC.
Certain tumors have also revealed coexpression of desmin, vimentin, epithelial membrane antigen, and smooth muscle actin, EAAT4, MUC4, NFP, and CD56.