MUC1


Also found in: Acronyms.

MUC1

A 265- to 400-kD transmembrane glycoprotein encoded by MUC1 on chromosome 1q21, which is found in milk-fat globule membranes.

Normal expression
Normal epithelia and perineurial cells, choroid plexus, arachnoid granulation, epithelioid histiocytes.

Abnormal expression
Neoplastic epithelia, meningiomas, mesotheliomas, mesenchymal tumours, some lymphomas, anaplastic large cell lymphomas.
References in periodicals archive ?
Mucins MUC1, MUC2, MUC5AC and MUC6 expression in the evaluation of differentiation and clinico-biological behaviour of gastric carcinoma.
Dr Kat Arney, of Cancer Research UK, said: "There are several groups around the world investigating treatments that target MUC1 as it's a very interesting target involved in several types of cancer.
From a cohort of 143 patients with epithelial ovarian cancer, preoperative blood samples obtained at primary diagnosis were subjected to immunomagnetic CTC enrichment and subsequent molecular CTC characterization, analyzing the transcripts of EPCAM, MUC1, and MUC16 (Adnatest OvarianCancer).
Pathogenesis of invasive micropapillary carcinoma: role of MUC1 glycoprotein.
The tumour-associated MUC1 protein is adorned with a distinctive, shorter, set of carbohydrates that set it apart from healthy cells.
Gendler says MUC1 is found on more than 70 percent of all cancers that kill.
ImMucin is an immunotherapeutic treatment which educates the MM patient's immune system, particularly T-cells and antibodies, to attack MM cancer cells via a specific domain, termed signal peptide, of the tumor marker MUC1.
Merck Serono, the biopharmaceutical division of Merck, today announced the initiation of the international Phase III START2 study, which is designed to assess the efficacy and safety of its investigational MUC1 antigen-specific cancer immunotherapy tecemotide (also known as L-BLP25) in patients with unresectable, locally advanced Stage III non-small cell lung cancer (NSCLC).
The assay's limitations, which derive from the fact that MUC1 is also expressed on activated T lymphocytes, should be considered (22).
2,3,57,58) Instead, GB MCs show expression of MUC1, a marker of aggressive phenotype in the pancreatobiliary tract, which is not seen in pancreatic colloid carcinomas, which are known to be associated with protracted clinical course.
To overcome this, researchers from the University of Georgia and the Mayo Clinic in the United States focused on a protein called MUC1 that is made in bigger amounts in cancerous cells than in healthy ones.
BrevaRex MAb targets the tumor associated antigen MUC1 and has successfully completed a Phase I safety and immunology study.