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an antimetaboliteantineoplastic agent that inhibits the conversion of folic acid to tetrahydrofolic acid by binding the enzyme dihydrofolate reductase, thus inhibiting DNA synthesis; it is specific for the S phase of the cell cycle. Used as the base and the sodium salt in the treatment of leukemias, lymphomas, sarcomas, and cancer of the head and neck, breast, colon, lung, testes, and other organs. Called also MTX. It is also used in the treatment of psoriasis and rheumatoid arthritis. Administered orally, intravenously, intramuscularly, intrathecally, or intra-arterially.


Methotrexate, see there.

Patient discussion about MTX

Q. Is methotrexate available in the United States as a treatment for fibromyalgia? Last year I was diagnosed as fibromyalgia. I feel a lot of fatigue and stiffness. I came upon a website from where I read that rheumatoid arthritis causes those same symptoms and can be treated with methotrexate. After reading that, I purchased a half year supply of the drug over the counter in Mexico. It eliminated all of my symptoms. A month after my supply ran out, all the symptoms returned. Is methotrexate available in the United States as a treatment for fibromyalgia?

A. Yes fatigue and stiffness are some of the symptoms of fibromyalgia. Methotrexate is certainly available in the United States, but it is not approved for nor used as a treatment for fibromyalgia. It was originally developed to treat cancer and subsequently found to be very effective for a number of inflammatory disorders, such as RA and psoriasis. Because fibromyalgia is not an inflammatory disorder – that is, there is no identifiable inflammation in the muscles or joints in individuals with this condition – it is not clear why you responded to this drug. You should tell your physician about your response to methotrexate. It may be possible that you have an inflammatory disorder rather than – or in addition to – fibromyalgia.

More discussions about MTX
References in periodicals archive ?
The supernatant contains unentrapped MTX was removed and the remaining pellet in the centrifuge tube resuspended in 0.
The PREMIER study, published in 2006, (6) described the results of a 2-year, multicenter, RCT comparing combination therapy (adalimumab and methotrexate) versus MTX (20 mg/week) or adalimumab (40 mg every other week) alone in patients with early (< 3 years of disease), aggressive RA who had not been previously exposed to MTX.
2] rapidly hydrolyzes the C-terminal glutamate from MTX to form the inactive compounds 2,4diamino-[N.
To reduce such effects, it would clearly be preferable to administer MTX topically [10].
As the improved safety and tolerability of CH-1504 is expected to be a significant advantage over MTX, the trial will also compare a cluster of gastrointestinal system related adverse events, such as nausea, vomiting, and diarrhea, frequently seen with MTX use as well as closely monitor the results of standard liver function tests across dose groups.
The hospital course for each treatment is usually 3-5 days or until the serum MTX level is less than 0.
CTI), announced an order valued at $884,329 for a CTI MTX 256 Tech Control Switching System, for the United States Army at Camp Roberts, California.