MMP14

(redirected from MT-MMP)

MMP14

A gene on chromosome 14q11-q12 that encodes matrix metalloproteinase 14, which specifically activates progelatinase A. It may be involved in actin cytoskeleton reorganisation by cleaving PTK7. Unlike other matrix metalloproteinases, which are secreted as inactive proproteins and activated when cleaved by extracellular proteinases, MMP14 is a transmembrane protein that is activated from its precursor by furin endopeptidase cleavage.

Molecular pathology
MMP14 may trigger invasion by tumour cells by activating progelatinase A on the surface of tumour cells.
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References in periodicals archive ?
sup][15] Imbalance among MMPs, MT-MMP and TIMPs result in alterations in MMP activity and contribute to pathological deposition in vascular collagen as well as remodeling of resistance arteries in hypertension.
Por otro lado, se encuentran las MMP asociadas a membrana o MT-MMP que tienen una funcion importante en la activacion de progelatinasas como resultado de la degradacion de gran cantidad de componentes de la MEC.
As MMPs podem ser ativadas por componentes nao proteoliticos, proteinases serinas, MT-MMPs ou podem ser ativadas no meio intracelular (12).