STK3

(redirected from MST2)

STK3

A gene on chromosome 8q22.2 that encodes a stress-activated, pro-apoptotic kinase which, following caspase cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. STK3 and STK4 are key components of the Hippo signalling pathway, which controls organ size and suppresses tumours by restricting proliferation and promoting apoptosis. STK3 is also a less preferred gene symbol for what is now designated as STK24, see there.
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MOBKL1A/MOBKL1B phosphorylation by MST1 and MST2 inhibits cell proliferation.
3) Sequence boundary Tc 2: According to Duarte (1997a; 1997b - herein designated as DT2) this sequence boundary marks the boundary between tenuicostatum and serpentinum Zone and between MST1 and MST2.
4) Depositional sequence Tc 2: In the Maria Pares section (Z) this sequence starts with the Calcarios em Plaquetas which, according to Duarte (1997a; 1997b), are the basal part MST2A of the mesosequence MST2 and document eustatic sea level fall.