STK24

(redirected from MST-3)

STK24

A gene on chromosome 13q31.2-q32.3 that encodes a serine/threonine-protein kinase which acts on serine and threonine residues and promotes apoptosis in response to stress stimuli and caspase activation. STK24 mediates oxidative-stress-induced cell death by phosphorylating JNK1-JNK2 (MAPK8 and MAPK9) and p38 (MAPK11, MAPK12, MAPK13 and MAPK14) during oxidative stress. It regulates cellular migration by altering PTPN12 activity and PXN phosphorylation, and it may be a key regulator of axon regeneration in the optic and radial nerves.