mendelian susceptibility to mycobacterial disease

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mendelian susceptibility to mycobacterial disease

An inherited syndrome characterised by predisposition to clinical disease caused by weakly virulent mycobacterial species (e.g., bacillus Calmette-Guerin (bCG)) vaccines, non-tuberculous environmental mycobacteria, including slow growing forms (e.g., M avium, M intracellulare, M kansasii, M malmoense, M simiae, M szulgai, M xenopi) and rapid growers (e.g., M abscessus, M chelonae and M fortuitum), and are susceptible to the more virulent strains of M tuberculosis.

Molecular pathology
MSMD is caused by a mutation of IKBKG on chromosome Xq28.