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The MSLT consists of a series of nap studies performed throughout the day.
Prior to the MSLT, patients should use CPAP for an adequate period of time to become accustomed to the device, as well as have experienced the benefits of treatment.
In addition to being objective, standardized, and well validated, the MSLT has the advantage of being easily administered to school-age children and also can be used to assess the response to treatment.
The normally alert subjects -- who appeared less sleep-deprived to begin with -- improved slightly, taking at least 16 minutes to fall asleep during the initial MSLT and an average of 18 minutes on the last day.
In addition, hyperarousal may account for longer than expected sleep latencies on MSLT tasks and potentially create a barrier to consistent SWS.
To minimize the effects of possible sleep deprivation, the American Academy of Sleep Medicine recommends that the patient have at least six hours of recorded sleep on the night prior to the MSLT (34).
That hypocretin levels are measured in the cerebral spinal fluid leading you to conclude that it is less invasive to do an MSLT than to diagnose this disorder biochemically.
The data showed NUVIGIL significantly improved wakefulness in the participants, as assessed by the MSLT averaged across days one and two.
The MSLT technology tests for the first sign of degeneration -- thickening, does not require any pupil dilation or dyes and is a very rapid test.
Patients taking NUVIGIL (150 mg) showed a statistically significant improvement over placebo as measured by the MSLT [p<0.
Her MSLT showed a mean sleep latency <5 minutes and 3 SOREMS.
Initial analyses showed that both doses of EVT 201 produced a statistically significant overall improvement in the MSLT compared to placebo, indicating that patients were less sleepy during the day following treatment with EVT 201.
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