S100A12

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S100A12

A gene on chromosome 1q21 that encodes a member of the S100 family of proteins, which contain 2 EF-hand calcium-binding motifs and as a group regulate cell cycle progression and differentiation and other cellular processes. The S100A12-encoded protein may be involved in calcium-dependent signal transduction pathways; its regulatory effect on cytoskeletal components may modulate neutrophil activities and trigger the release of cytokines.
References in periodicals archive ?
If the lack of MRP6-transport activity for certain antioxidants were the cause of oxidative stress and subsequent impairment in the assembly of the extracellular matrix, one would expect even greater damage in tissues with high MRP6 concentrations, which is obviously not the case.
Pseudoxanthoma elasticum: mutations in the MRP6 gene encoding a transmembrane ATP-binding cassette (ABC) transporter.
This subgroup contains PXE patients most likely to have either no MRP6 protein or no functional MRP6.
Expression of human MRP6, a homologue of the multidrug resistance protein gene MRP1, in tissues and cancer cells.
MRP6 (ABCC6) detection in normal human tissues and tumors.
In the present study, we evaluated the association between serum fetuin-A, calcium and phosphate, and the PXE phenotype to investigate the link between an absence or functional insufficiency of MRP6 and mineralization of elastic fibers in PXE.
MRP6 is localized to the basolateral side of human hepatocytes and membranes of kidney proximal tubules, indicating that MRP6 extrudes unknown substrates into the blood.
To determine the link between MRP6 and the pathologic calcification in PXE, we investigated the production of fetuin-A in PXE patients.
T256S polymorphisms did not differ among PXE patients, relatives, and controls; we therefore conclude that the difference in fetuin-A concentrations results from MRP6 deficiency and not from a genetic background.