MRC study

MRC study

A clinical trial that evaluated the efficacy of drug therapy—beta-blockers (amiloride or atenolol)—and diuretics in older hypertensives

Conclusion
Hydrochlorothiazide and amiloride are better than atenolol in reducing hypertension-related events—strokes and coronary events—in older hypertensive patients.

Logistics
Randomised, single-blind, placebo-controlled multicenter trial.

Size 4396 patients.

Selection criteria Age 65–74, systolic BP ≥ 160–209, and diastolic BP < 115 mm Hg.