MPTP


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MPTP

Piperidine derivative that causes irreversible symptoms of parkinsonism in humans and monkeys. A by-product of illicitly manufactured meperidine that caused numerous cases of parkinsonism. Used as an experimental tool in research on parkinsonism.

MPTP

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, analogs MTMP, PEPAP Neurology A potent neurotoxin–which has an effect much like Meperidine or Demerol—that acts on neuromelanin, producing parkinsonism Clinical Bradykinesia, muscular rigidity, resting tremor, defects of posture and gait Pharmacologic effects MPTP initially blocks the brain's responses to pain, then metabolizes to MPP+, causing an irreversible syndrome resembling Parkinson's disease. See BDNF, Designer drugs, Parkinson's disease.
References in periodicals archive ?
Low does of MPTP cause extensive cell loss in the substantia nigra of both humans and monkeys, note the researchers.
Diethyldithiocarbamate causes nigral cell loss and dopamine depletion with nontoxic doses of MPTP.
Bakay and his colleagues administered MPTP to rhesus monkeys.
Several chemicals in the pyridine group are similar in structure to MPTP and exist in the environment, especially in foods, write Snyder and Robert J.
MPTP is a toxin that induces a severe and irreversible Parkinson's Disease-like syndrome.
Because MPTP produces Parkinson's disease much more rapidly than Mother Nature and amyloid formation results from the Alzheimer's disease process rather than being a primary cause of it, it was necessary for researchers to focus on how and why much earlier components of damage occur, and how the damage could be prevented.
One such environmental link is a neurotoxin known as MPTP (l-methyl-4-phenyl-l,2,3,6-tetrahydropyridine; Smeyne & Jackson-Lewis, 2005).
The MDA event kicks off an ambitious phase of the Saudi government organization's MPTP initiative.
With a massive expansion of The Prophet's Mosque in Madinah still taking place, the MPTP is aimed at providing a public transport network to serve the city's residents and religious tourists alike.
Effects of metabolic modifiers such as carnitines, coenzyme Q10, and PUFAs against different forms of neurotoxic insults: metabolic inhibitors, MPTP, and methamphetamine.
Additional potential neuroprotective effects of curcumin and/or the curcuminoids include as an antidepressant; protection against aluminium induced neurotoxicity, ethanol-induced brain damage, sodium-arsenite toxicity, 3-nitorpropionic acid-induced toxicity, MPTP toxicity, traumatic brain injury, lead induced neurotoxicity, glutamate toxicity and brain focel ischemia; memory improvement by HIV glycoprotein; anti aging; reversal of amyloid pathology and ethanol induced neurotoxicity; and restoration of the synaptic plasticity.