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MPTP |
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MPTP
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, analogs MTMP, PEPAP Neurology A potent neurotoxin–which has an effect much like Meperidine or Demerol—that acts on neuromelanin, producing parkinsonism Clinical Bradykinesia,
muscular rigidity, resting tremor, defects of posture and gait Pharmacologic effects MPTP initially blocks the brain's responses to pain, then metabolizes to MPP+, causing an irreversible syndrome resembling Parkinson's disease. Cf
BDNF, Designer drugs, Parkinson's disease. Want to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit the webmaster's page for free fun content. |
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While MPTP does not cause Parkinson's disease, scientists regularly use it as a model for the disease because it causes an identical type of brain damage. Further tests have found that MPTP can cause damage to neurons in the substantia nigra in the brain--the dopamine-producing area that dies in Parkinson's--and can disrupt mitochondrial function. Early and late molecular events in neurodegeneration and neuroprotection in Parkinson's disease MPTP model as assessed by cDNA microarray; the role of iron. |
MPTP |
MPTB MPTBA MPTC MPTCD MPTCL MPTCP MPTD MPTDC MPTDS MPTDSS MPTE MPTER MPTER Model with Deposition and Settling of Pollutants MPTF MPTFE MPTFO MPTG MPTI MPTIS MPTK MPTL MPTM MPTN MPTO MPTP Mptp poisoningMPTQM MPTR MPTRR MPTRRD MPTS MPTS2 MPTSA MPTT MPTTA MPTV MPTY MPTZ MPU MPU MPU MPU 401 MPU-401 MPU401 MPUA MPUAT Mpuc MPUD MPUE MPUF MPUFB | ||||||||
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