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While MPGN remains the most common renal disease associated with HCV, membranous nephropathy, fibrillary glomerulonephritis, rapid progressive glomerulonephritis, and IgA nephropathy have also been reported in patients with HCV.
Soliris is not approved for the treatment of aHUS, MPGN, CAPS or diarrhea-associated HUS (D+HUS).
Rationale for Terminal Complement Inhibition in Patients with MPGN MPGN is a rare and progressive renal disease that is typically found in children and young adults.
Researchers report on three patients with MPGN, two with MPGN type I and one with MPGN type II or DDD, with different clinical courses and biopsy results.
Increased mesangial cellularity is a typical finding in the type-1 MPGN, whereas in diabetic nephropathy, there are a few more cells located at the periphery of the nodule.
Type-II MPGN can have various glomerular appearances on light microscopy; the defining feature is intramembranous, dense deposits identified by electron microscopy.
Immunofluorescence findings in type-I MPGN are typical of a fine to coarse, granular pattern along the glomerular capillaries with C3, but of lesser intensity with immunoglobulins.
When he got sick and was diagnosed with MPGN type two, since then he has been on the dialysis machine for 12 hours a day, seven days a week.
Eoin was a perfectly normal, healthy 10-year-old when his family received the devastating news that he was suffering from MPGN Type 2.