KAT6B

(redirected from MOZ, YBF2/SAS3, SAS2 and TIP60 protein 4)

KAT6B

A gene on chromosome 10q22.2 that encodes a histone acetyltransferase which, depending on the context, up- or downregulates transcription. KAT6B is required for RUNX2-dependent transcriptional activation and may be involved in development of the cerebral cortex. It is part of the MOZ/MORF complex, which has histone H3 acetyltransferase activity.

Molecular pathology
Defects in KAT6B are a cause of genitopatellar syndrome and Ohdo syndrome (SBBYS variant). Chromosomal defects  of KAT6B have been linked to acute myeloid leukaemias via translocation t(10;16)(q22;p13) with CREBBP.