SAMHD1

(redirected from MOP5)

SAMHD1

A gene on chromosome 20pter-q12 that encodes a putative nuclease involved in the innate immune response, which acts by downregulating cell-intrinsic antiviral response. It may play a role in mediating pro-inflammatory responses to TNF-alpha signalling. It is expressed in the heart, skeletal muscle, spleen, liver and elsewhere, but not in the brain or thymus.

Molecular pathology
Defects in SAMHD1 cause Aicardi-Goutieres syndrome type 5 and chilblain lupus type 2.
References in periodicals archive ?
The Macau banking sector ended the 2012 financial year with customer deposits valued at over MOP550bn, profits of over MOP5.
true] shown in Figure 2, it can be observed that even though MOGA2 obtained a better distribution of solutions (better value of S metric), for the MOP5 function, it can not approximate the top portion of the Pareto front.
Table 1: Parameter Settings Parameters SMPSO MOP5 MOP6 MOPC1 Iterations 7000 3000 2000 Extern file size 799 799 799 Crossover prob.