MOCS2

MOCS2

A gene on chromosome 5q11 that encodes the catalytic subunit of the molybdopterin synthase complex, which catalyses the conversion of precursor Z into molybdopterin.

Molecular pathology
Defects in MOCS2 cause molybdenum cofactor deficiency type B.
References in periodicals archive ?
The DNA-quality assay was based on dPCR measurement of amplifiable DNA associated with 4 different amplicons with sizes of 78, 159, 197, and 550 bp, which corresponded to amplicons within the SPINT1 (serine peptidase inhibitor, Kunitz type 1), INTS2 (integrator complex subunit 2), MOCS2 (molybdenum cofactor synthesis 2), and PRP8 [PRP8 premRNA processing factor 8 homolog (S.
1B) of the SPINT1 (78 bp) fragment produced a strong fluorescence signal on the VIC channel (VIC is a proprietary dye of Applied Biosystems/Life Technologies) because of the relatively high concentration of the VIC probe specific for the SPINT1 gene, whereas amplification of the MOCS2 (197 bp) sequences yielded a weaker signal on the VIC channel owing to the lower concentration of the VIC probe specific for the MOCS2 gene.
6] KRAS, v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog; EGFR, epidermal growth factor receptor; SPINT1, serine peptidase inhibitor, Kunitz type 1; INTS2, integrator complex subunit 2; MOCS2, molybdenum cofactor synthesis 2; PRP8, pre-mRNA processing factor 8.