EPCAM

(redirected from MOC31)

EPCAM

A gene on chromosome 2p21 that encodes a carcinoma-associated antigen expressed on most normal epithelial cells and gastrointestinal carcinomas, which functions as a homotypic calcium-independent cell adhesion molecule. EPCAM is thought to function as a relay molecule between intestinal epithelial cells and intraepithelial lymphocytes at the mucosa, providing an immune barrier to infection. It is of interest in oncology as a target for cancer immunotherapy. It upregulates expression of FABP5, MYC and cyclins A and E.

Molecular pathology
Defects in EPCAM cause congenital tufting enteropathy (diarrhoea type 5).
References in periodicals archive ?
Hepatoid carcinomas may also express MOC31 and mCEA, which are infrequently expressed in HCCs.
Histologic specimens obtained at surgery were fixed in 10% formalin, routinely processed and embedded in paraffin All specimens were evaluated immunohistochemically with antibodies calretinin, vimentin, CK5/6, MOC31, CD15 and CEA using staining procedures.
The diagnostic utility of MOC31, BerEP4, RCC marker and CD10 in the classification of renal cell carcinoma and renal oncocytoma: An immunohistochemical analysis of 328 cases.
17) In contrast, CA9, (13,19) MOC31, (11) c-kit, (19) VEGFR-2, (19) PDGFR-[alpha], (19) and TFE (18) were not detected.
The most useful general carcinoma markers are MOC31, BG8, carcinoembryonic antigen, and BerEp4.
Lung Adenocarcinoma Versus Mesothelioma (Second IHC Panel) Marker Lung Adenocarcinoma Mesothelioma Napsin A + - MOC31 + - CEA + - CK5/6 - + Thrombomodulin -/+ + HBME1 -/+ + Abbreviations: CEA, carcinoembryonic antigen; CK5/6, cytokeratin 5/ 6; HBME1, Hector Battifora mesothelial/1; IHC, immunohistochemical; +, greater than 75% of cases are positive; -, fewer than 5% of cases are positive; -/+, fewer than 50% of cases are positive.
Among them, MOC31 has been demonstrated to be one of the best epithelial markers expressed in a broad spectrum of carcinomas.
The tumor cells were negative for pancytokeratin, cytokeratin 7, cytokeratin 20, mammaglobin, MOC31, PAX-8, estrogen receptor, TTF1, polyclonal carcinoembryonic antigen, CDX2, BerEP4, Hep Par 1, calretinin, synaptophysin, CD56, CD10, S100, Melan-A, desmin, actin, CD34, factor 8, and inhibin.
Alternative epithelial markers in sarcomatoid carcinomas of the head and neck, lung, and bladder--p63, MOC31, and TTF-1.
Original Diagnosis Consult Type Diagnosis Cervical biopsy 3 SIL Benign Prostate biopsy 4 Carcinoma Benign Breast biopsy 3 Invasive carcinoma DCIS arising in DCIS Pleural fluid 1 Adenocarcinoma Benign Stomach biopsy 1 Adenocarcinoma Benign granulation tissue Biopsy Site/ Comment Method to Potentially Prevent Error Type Cervical biopsy No IHC done p16, MIB-1 in selected cases Prostate biopsy No IHC done p63, HMWK, AMACR in selected cases Breast biopsy No IHC done p63 in selected cases Pleural fluid No IHC done BER-EP4, MOC31 in selected cases Stomach biopsy No IHC done Keratin, CD68 in selected cases Abbreviations: DCIS, ductal carcinoma in situ; HMWK; high-molecular-weight keratin; IHC, immunohistochemistry; SIL, squamous intraepithelial lesion.
2, CK [cytokeratin] 7, CK20, CK17, CK19, MUC1, MUC2, MUC4, MUC5AC, MUC6, p53, DPC4/ SMAD4, CDX2, pVHL [von Hippel-Lindau tumor suppressor gene protein], S100P, IMP-3 [insulin-like growth factor 2 messenger RNA binding protein 3], maspin, mesothelin, claudin 4, claudin 18, annexin A8, fascin, PSCA [prostate stem cell antigen], MOC31, CEA [carcinoembryonic antigen], and CA19-9 [cancer antigen 19-9]) in the diagnosis of ductal adenocarcinoma of the pancreas by using 60 cases of pancreatic DAC on routine and tissue microarray (TMA) sections.