MNF116

MNF116

A broad-spectrum anti-keratin antibody that reacts with intermediate and low-molecular-weight keratins, which labels a number of discrete bands ranging from 40 to 58 kDa, corresponding to cytokeratins 5, 6, 8, 17 and probably 19.
References in periodicals archive ?
MNF116 labels epithelial tissues from simple glandular to stratified epithelium and is a useful tool for the identification of normal and neoplastic cells of epithelial origin.
MNF116 is used at a dilution range of 1:100 and applied to formalin-fixed, paraffin-embedded sections of SLN, using 20 minutes' heat-induced epitope retrieval.
The tumour cells were negative for cluster of differentiation (CD) 117, CD34, CD99, CD68, S100, Activin receptor-like kinase-1, MNF116, and Human Melanoma Black -45.
Immunohistochemistry was performed, and the tumor cells showed negative expression for MNF116, L26, and CD45RO (UCHLI).
1-4) Several authors have established that immunostains for cytokeratins (CKs), such as CK MNF116 and CK 5/6, as well as the myoepithelial cell marker p63, are variably positive in the spindle cells of metaplastic carcinomas and are helpful in supporting the diagnosis.
All 55 cases were immunostained with CK 5/6, CK 903, CK MNF116, and p63.
Squamous cell carcinoma with single cell infiltration: a potential diagnostic pitfall and the utility of MNF116 and p63.
F, Lack of cytokeratin MNF116 expression in lesional cells, with staining of adjacent epidermis.
Chia and colleagues (69) investigated a larger cohort of PTs using a wide panel of commonly used keratins, including MNF116, 34[beta]E12, CK7, CK14, Cam5.
To support the diagnosis of metaplastic carcinoma, we performed an immunohistochemical stain panel, which showed that the spindle cell results were positive for CK903, MNF116, and p63 and negative for a cytokeratin cocktail (CK AE1/AE3 and CAM 5.
MNF116 recognizes cytoplasmic polypeptides of 45, 46, and 56.