In our study, MMTV
particles resembled those described by other investigators (Bernhard >et al.
In 2007, a research team writing in the journal Retrovirology used updated genetic techniques to show, for the first time, evidence that MMTV
could replicate inside human cells.
The prevalence of the MMTV
env gene appears to be particularly high in tumor specimens from women with more aggressive forms of breast cancer.
31,32) Recently published data have shown that the ITAM-containing MMTV
ENV protein of mice can transform in vitro both mouse and human breast tissue.
5] Human genes: CBFB, core-binding factor, beta subunit; RUNX1, runt-related transcription factor 1; MAGI3, membrane associated guanylate kinase, WW and PDZ domain containing 3; AKT3, v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma); MAGI3-AKT3, fusion of genes MAGI3 and AKT3; KRAS, v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog; CT-NNB1, catenin (cadherin-associated protein), beta 1, 88kDa; SMARCA4, SWI/ SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4; CREBBP, CREB-binding protein; WNT, wingless-type MMTV
integration site family; BRAF, v-raf murine sarcoma viral oncogene homolog B1.
Live can be seen from today /SAT/ to February 22.
Mice transmit MMTV
to their offspring through milk, but epidemiological studies provide no evidence that children breast-fed by mothers with breast cancer face an increased risk of the disease.
Symbol Entrez gene name WNT16 Wingless-type MMTV
integration site family, member 16 PLCD4 Phospholipase C, delta 4 ADAM29 ADAM metallopeptidase domain 29 MMP8 Matrix metallopeptidase 8 (neutrophil collagenase) EPHA6 EPH receptor A6 PAK7 p21 protein (Cdc42/Rac)-activated kinase 7 EPHA7 EPH receptor A7 EPHA3 EPH receptor A3 SEMA6D Serna domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D ADAM30 ADAM metallopeptidase domain 30 UNC5D Unc-5 homolog D (C.
Relative to unselected cells, AHR-positive cells showed a time-dependent decrease of expression of GO categories involved in a) cardiac differentiation and morphogenesis, b) increasingly lower expression of categories involved in WNT (wingless-related MMTV
integration site 3A) signaling and regulation of gastrulation, c) gametogenesis, and d) high levels of expression of genes involved in drug and xenobiotic metabolism (Figure 2B; see also Supplemental Material, Table S3).
2+] pathway including wingless-type MMTV
integration site family, member 5A (Wnt5A), frizzled homolog 1 (FZD1), and protein kinase C genes in mammary tissues compared to liver.
The resulting cDNAs were subjected to real-time RT-PCR for PTEN (phosphatase and tensin homolog), VIM (vimentin), E-CAD (E-cadherin), SNAIL1 (SNAI1 snail family zinc finger 1), TWIST1 (twist basic helix-loop-helix transcription factor 2), ABCG-2 [ATP-binding cassette, sub-family G (WHITE), member 2], OCT-4 (POU class 5 homeobox 1), and WNT-3 (wingless-type MMTV
integration site family, member 3) as described previously (Tokar et al.
In contrast, low-grade endometrioid carcinoma develops from endometriotic cysts that have aberrations in the wingless-type MMTV
integration site family (Wnt) signaling pathway, including mutations of catenin (cadherin-associated protein), [beta] 1 (CTNNB1); phosphatase and tensin homolog (PTEN); and phosphoinositide-3-kinase, catalytic, [alpha] polypeptide (PIK3CA) genes.