MMP14

MMP14

A gene on chromosome 14q11-q12 that encodes matrix metalloproteinase 14, which specifically activates progelatinase A. It may be involved in actin cytoskeleton reorganisation by cleaving PTK7. Unlike other matrix metalloproteinases, which are secreted as inactive proproteins and activated when cleaved by extracellular proteinases, MMP14 is a transmembrane protein that is activated from its precursor by furin endopeptidase cleavage.

Molecular pathology
MMP14 may trigger invasion by tumour cells by activating progelatinase A on the surface of tumour cells.
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In addition, it has been previously reported that exosomes secreted by CSCs can transport proteins, including MMP14, to vascular endothelial cells.
Evidence for the involvement of MMP14 in MMP2 processing and recruitment in exosomes of corneal fibroblasts.
MiR-34a inhibits migration and invasion of tongue squamous cell carcinoma via targeting MMP9 and MMP14.
For instance, TIMP1 strongly inhibits many MMPs excepting membranar type, including MMP14,-15,-16,-19 and -24 [30, 32].
In turn, it led to a decrease in TCF/LEF transcriptional activity and decreased expression of target genes such as Axin2 and MMP14.
The inflammation process is boosted by chemokines and cytokines such as NF-kB and components of the extracellular matrix (ECM) such as macrophages, fibroblasts, and mast cells that may negatively influence the structure of ECM through the production of proteases, MMP2, and MMP14 that have shown elevated expression in situ, responding to invasive carcinoma transition (ICT).
Tambien modificadores de la sintesis de colageno como LOXL1 y SERPINH1, proteinas que remodelan la matriz extracelular como MMP2, MMP9, MMP14, PLAU y TIMP2 y factor de crecimiento de tejido conectivo (CTGF).
2E-11 factor receptor activity BMP8B, CSF1, FCFR1, BMPR2, 1GF2R, PDCFB, TGFBR2, NRP1, CCR2 Biosynthetic process CEL, COL11A2, ACPP, MMP14, 1.
Among the genes of the MMPs family spotted on our array, MMP1, MMP12 (macrophage elastase), MMP14, and MMP-19 had enhanced expression in subjects from the high-level arsenic exposure group.
A correlation between metalloproteinase MMP14 expression and overall survival was reported in 1 study of 9 patients with MPM treated by standard thoracotomy for therapeutic purposes, compared to 4 normal pleural samples.
Macrophages produce TGF-beta-induced (beta-ig-h3) following ingestion of apoptotic cells and regulate MMP14 levels and collagen turnover in fibroblasts.