MMP11

MMP11

A gene on chromosome 22q11.23 that encodes matrix metalloproteinase 11. Unlike other matrix metalloproteinases, which are secreted as inactive proproteins and activated when cleaved by extracellular proteinases, MMP11 is activated intracellularly by a furin endopeptidase. It cleaves alpha 1-proteinase inhibitor, but only weakly acts on the structural proteins of the extracellular matrix.

Molecular pathology
MMP11 may play a key role in the progression of epithelial malignancies, and is specifically expressed in stromal cells of breast carcinomas.
References in periodicals archive ?
MMP3 is expressed in tumoral stroma of invasive breast cancer along with MT1-MMP, MMP1, MMP2, and MMP11 [105].
Due to MMP11 involvement in neoangiogenesis, its absence results in breast carcinogenesis inhibition and similarly pancreatic carcinogenesis is reduced by the lack of MMP2 and by of MMP9 [23, 109, 110].
MMP11 has an inhibitory action on tumor cell apoptosis but, paradoxically, an unknown mechanism of metastasis prevention has been demonstrated in experiments in transgenic mice [130].
Metastatic and non-metastatic colorectal cancers variably express MMPs along with their specific inhibitors, such as MMP1, MMP2, MMP3, MMP7, MMP9, MMP10, MMP11, and MMP13 [54].
In breast cancer, MMP11 derived from cancer-associated adipocytes or fibroblastic cells exerts type VI collagenolytic activity (40).
While the majority of these 16 genes were found to be estrogen receptor-related (ESR1, PGR, BCL2, SCUBE2) and proliferation-related (Ki67, STK15, Survivin, CCNB1, MYBL2), some genes did not belong to these 2 categories (HER2, GRB7, MMP11, CTSL2, GSTM1, CD68, BACG1).
T]SL2, cathepsin L2; ESR1, estrogen receptor 1; GRB7, growth factor receptor-bound protein 7; GSTM1, glutathione S-transferase M1; ERBB2, v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian); MKI67, antigen identified by monoclonal antibody Ki-67; MYBL2, v-myb myeloblastosis viral oncogene homolog (avian)-like 2; PGR, progesterone receptor; AURKA, aurora kinase A; MMP11, matrix metallopeptidase 11 (stromelysin 3); BIRC5, baculoviral IAP repeat-containing 5 (survivin); ACTB, actin, beta; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; GUSB, glucuronidase, beta; KPLPO, ribosomal protein, large, P0; TFRC, transferrin receptor (p90, CD71).
a) Common Sequence ID Official gene gene name symbol BAG1 NM_004323 BAG1 Bcl2 NM_000633 BCL2 CCNB1 NM_031966 CCNB1 CD68 NM_001251 CD68 CEGP1 NM_020974 SCUBE2 CTSL2 NM_001333 CTSL2 EstR1 NM_000125 ESR1 GRB7 NM_005310 GRB7 GSTM1 NM_000561 GSTM1 HER2 NM_004448 ERBB2 Ki-67 NM_002417 MKI67 MYBL2 NM_002466 MYBL2 PR NM_000926 PGR STK15 NM_003600 AURKA STMY3 NM_005940 MMP11 SURV NM_001168 BIRC5 -Actin NM_001101 ACTB GAPDH NM_002046 GAPDH GUS NM_000181 GUSB RPLPO NM_001002 RPLP0 TFRC NM_003234 TFRC (a) Genes annotated with NCBI LocusLink sequence identification numbers and official gene symbols of the HUGO Gene Nomenclature Committee (http://www.