MMP3 is expressed in tumoral stroma of invasive breast cancer along with MT1-MMP, MMP1, MMP2, and MMP11 .
Due to MMP11 involvement in neoangiogenesis, its absence results in breast carcinogenesis inhibition and similarly pancreatic carcinogenesis is reduced by the lack of MMP2 and by of MMP9 [23, 109, 110].
MMP11 has an inhibitory action on tumor cell apoptosis but, paradoxically, an unknown mechanism of metastasis prevention has been demonstrated in experiments in transgenic mice .
Metastatic and non-metastatic colorectal cancers variably express MMPs along with their specific inhibitors, such as MMP1, MMP2, MMP3, MMP7, MMP9, MMP10, MMP11, and MMP13 .
In breast cancer, MMP11
derived from cancer-associated adipocytes or fibroblastic cells exerts type VI collagenolytic activity (40).
While the majority of these 16 genes were found to be estrogen receptor-related (ESR1, PGR, BCL2, SCUBE2) and proliferation-related (Ki67, STK15, Survivin, CCNB1, MYBL2), some genes did not belong to these 2 categories (HER2, GRB7, MMP11
, CTSL2, GSTM1, CD68, BACG1).
T]SL2, cathepsin L2; ESR1, estrogen receptor 1; GRB7, growth factor receptor-bound protein 7; GSTM1, glutathione S-transferase M1; ERBB2, v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian); MKI67, antigen identified by monoclonal antibody Ki-67; MYBL2, v-myb myeloblastosis viral oncogene homolog (avian)-like 2; PGR, progesterone receptor; AURKA, aurora kinase A; MMP11, matrix metallopeptidase 11 (stromelysin 3); BIRC5, baculoviral IAP repeat-containing 5 (survivin); ACTB, actin, beta; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; GUSB, glucuronidase, beta; KPLPO, ribosomal protein, large, P0; TFRC, transferrin receptor (p90, CD71).
a) Common Sequence ID Official gene gene name symbol BAG1 NM_004323 BAG1 Bcl2 NM_000633 BCL2 CCNB1 NM_031966 CCNB1 CD68 NM_001251 CD68 CEGP1 NM_020974 SCUBE2 CTSL2 NM_001333 CTSL2 EstR1 NM_000125 ESR1 GRB7 NM_005310 GRB7 GSTM1 NM_000561 GSTM1 HER2 NM_004448 ERBB2 Ki-67 NM_002417 MKI67 MYBL2 NM_002466 MYBL2 PR NM_000926 PGR STK15 NM_003600 AURKA STMY3 NM_005940 MMP11 SURV NM_001168 BIRC5 -Actin NM_001101 ACTB GAPDH NM_002046 GAPDH GUS NM_000181 GUSB RPLPO NM_001002 RPLP0 TFRC NM_003234 TFRC (a) Genes annotated with NCBI LocusLink sequence identification numbers and official gene symbols of the HUGO Gene Nomenclature Committee (http://www.