MMP9

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MMP9

A gene on chromosome 20q12-q13 that encodes matrix metalloproteinase 9, which degrades collagens IV and V, gelatins I and V, and fibronectin. It is thought to play a key role in local proteolysis of the extracellular matrix and in leukocyte migration, and may play a role in osteoclastic resorption of bone.

Molecular pathology
Defects in MMP9 increase susceptibility to intervertebral disc disease and lumbar disc herniation; MMP9 defects cause metaphyseal anadysplasia type 2.
References in periodicals archive ?
In this study, we aimed to investigate whether clinical measures of disease activity and function in AS and IBD are associated with MMP-3, MMP-9 and TIMP-1, and if MMPs can be more useful than CRP and ESR in predicting disease activity in AS.
An increase of MMP-9 in the apical part of the epithelium in the polypoid tissue of the nasal cavity, maxillary sinus, and ethmoid sinus may facilitate the epithelial and endothelial cell migration that is observed during polyp development and growth.
Matrix metalloproteinase-9 (MMP-9) is implicated in the development of chronic vascular diseases including aneurysm, but the effective MMP-9 inhibitors are far from development.
Experts University of Louisville School of Medicine stated that the MMP-9 gene plays a major role in causing decline of cognitive and hearing functions and removal of the said gene decreases Hyperhomocysteinemia-induced cognitive and hearing dysfunctions said the research published in the Journal of Molecular Biology Reports.
MMP-9 and MMP-2 are the two most studied MMPs, and the two most frequently expressed MMPs in the nervous system (10).
It is believed that a very important function of MMP-2 and MMP-9 is in cell remodeling processes in the male and female reproductive system (Woessner, 1994; Hulboy et al.
Two MMPs in particular, MMP-2 and MMP-9, are thought to accelerate wrinkling by degrading the outer components of cells.
com)-- AnaSpec has announced the release of three new MMP recombinant proteins, MMP-1, MMP-9 and MMP-12.
acnes sonicate (effectively broken, unfractionated cells) induced MMP-1 ('interstitial collagenase') and MMP-9 messenger RNAs, and the expression of MMP-9, but not of MMP-1 was dependent on Toll-like receptor-2.
MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP12, and MMP-13 were simultaneously measured using the Fluorokine MultiAnalyte Profiling assays (R&D Systems) on a Luminex 100 Bioanalyzer (Luminex.
Pro-Sveltyl limits adipose tissue inflammation by stimulating the expression of adiponectin, and preserves fibrous architecture by inhibiting the activity of adipocytes MMP-2 and MMP-9.