MMP21

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MMP21

A gene on chromosome 10q26.13 that encodes matrix metalloproteinase 21, which cleaves alpha-1-antitrypsin and may have a role in embryogenesis and tumour progression. MMP21 is also a less preferred gene symbol for what is now designated as MMP23A (see there), and a less preferred gene symbol for what is now designated as MMP23B (see there).
References in periodicals archive ?
Retinoid receptor binding sites have been identified in the promoter region for MMP-21 expression, thus retinoic acid upregulates MMP21 mRNA in monocytic U937 cells [1] and the enzyme has been found in cancer cells.
7]M retinoic acid (RA) induced an upregulation of MMP-21 by 2.
In summary, the authors conclude that MMP-21 is expressed by suprabasal keratinocytes in certain benign disorders and is induced in differentiating keratinocytes, thus it may be an important protease in this process.
The present paper deals with a recently cloned member of the group, MMP-21, which has been implicated in fetal development, stromal remodelling, inflammation and cancer, but its physiological substrate(s) has not been identified.
A range of agents were tested for their ability to induce MMP-21 mRNA but only all-trans-retinoic acid ([10.