MMP17

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MMP17

A gene on chromosome 12q24.3 that encodes membrane-type matrix metalloproteinase 17. Unlike other matrix metalloproteinaes, which are secreted as inactive proproteins and activated when cleaved by extracellular proteinases, MMP17 is membrane bound as a GPI-anchored protein. It activates MMP2 by cleavage; it does not hydrolyse collagen types I, II, III, IV and V, gelatin, fibronectin, laminin, decorin or alpha1-antitrypsin.
References in periodicals archive ?
MMP-17, MMP-24 and MMP-25 were detected in kidneys not involved with tumour process [39].
Membrane type MMPs (MT-MMP) (MMP-14, MMP-15, MMP-16, MMP-17, MMP24, and MMP-25) are anchored to the plasma membrane by a transmembrane domain with a cytoplasmic domain or a glycosylphosphatidylinositol (GPI).
As MMPs pertencem a classe metalo, dependem de zinco para a sua acao catalitica e sao classificadas em cinco grupos: colagenases (MMP-1, MMP-8, MMP-13, MMP-18), gelatinases (MMP-2 e MMP-9), estromalisinas (MMP-3, MMP-10, MMP-11), MMPs tipo membrana (MMP-14, MMP-15, MMP-16, MMP-17, MMP-24, MMP-25) e outros (MMP-7, MMP-12, MMP-20 e MMP-26) (Tabela 1) (9, 12, 13).