MMP15

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MMP15

A gene on chromosome 16q13 that encodes matrix metalloproteinase 15, an endopeptidase that degrades components of the extracellular matrix and may activate progelatinase A. Unlike other matrix metalloproteinases, which are secreted as inactive proproteins and activated when cleaved by extracellular proteinases, MMP15 is a transmembrane protein that is activated from its precursor by furin endopeptidase cleavage.
References in periodicals archive ?
Four of them are classified as type I membrane proteins, MMP-14, MMP-15, MMP-16 and MMP-24, while remaining two (MMP-17 and MMP-25) are attached to the membrane by glycosylphosphatidylinositol molecule.
Membrane type MMPs (MT-MMP) (MMP-14, MMP-15, MMP-16, MMP-17, MMP24, and MMP-25) are anchored to the plasma membrane by a transmembrane domain with a cytoplasmic domain or a glycosylphosphatidylinositol (GPI).
As MMPs pertencem a classe metalo, dependem de zinco para a sua acao catalitica e sao classificadas em cinco grupos: colagenases (MMP-1, MMP-8, MMP-13, MMP-18), gelatinases (MMP-2 e MMP-9), estromalisinas (MMP-3, MMP-10, MMP-11), MMPs tipo membrana (MMP-14, MMP-15, MMP-16, MMP-17, MMP-24, MMP-25) e outros (MMP-7, MMP-12, MMP-20 e MMP-26) (Tabela 1) (9, 12, 13).