MMP13

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MMP13

A gene on chromosome 11q22.3 that encodes matrix metalloproteinase 13, which cleaves collagens I in the extracellular matrix. MMP13 may play a role in turnover of articular cartilage.

Molecular pathology
Defects in MMP13 cause spondyloepimetaphyseal dysplasia Missouri type and metaphyseal anadysplasia type 1. MMP13 may play a role in the pathogenesis of osteoarthritis.
References in periodicals archive ?
There appears to be strong inhibition of iNOS, MMP-9, MMP-13, NF-[kappa]B, TNF[alpha], IL-1, IL-2, IL-4, IL-6, and IFN[gamma], and the complement system.
7) MMP-13 (which stands for matrix metalloproteinase-13) dissolves cartilage, leaving the joint space unprotected and vulnerable to friction and traumatic injury.
MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP12, and MMP-13 were simultaneously measured using the Fluorokine MultiAnalyte Profiling assays (R&D Systems) on a Luminex 100 Bioanalyzer (Luminex.
At this time, MMP-13 and ADAMTS-5 (8,9) are identified as the most attractive targets for the treatment of OA, as recent reports have shown that both these enzymes are the predominant ones involved in the OA process.
The co-induction of NF-[kappa]B, MMP-13, and c-myc indicated in our microarray results is consistent with previous work by Tak and Firestein (2001).
Kim (SUNY at Buffalo) described effects of IMPACS on the expression of the gene for another enzyme involved in the destruction of bone, MMP-13 (collagenase 3).
The Company's lead MMP program has lead to the discovery of ALS 1-0635, an MMP-13 inhibitor, which is in preclinical development for the treatment of osteoarthritis.
Expression and localization of TIMP-1, TIMP-2, MMP-13, MMP-2, and MMP-9 in early and advanced experimental lung silicosis.
In the placebo group, there was a significant increase in the mean urinary levels of both CTX-1 (15%), CTX-II (9%) and in the mean serum levels of C2C (29%), MMP-13 (153%), MMP-3 (49%) and HA (25%).