PTEN

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PTEN

A gene on chromosome 10q23.3 which encodes PTEN (phosphatase and tensin homolog), a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase protein, which acts as a tumour suppressor by negatively regulating the AKT/PKB-signalling pathway.
References in periodicals archive ?
Schering-Plough has initiated a research program to develop cancer therapeutics based on the MMAC1 gene and its biochemical pathway.
The MMAC1 tumor suppressor is interesting because it is one of the first such genes to have a well-defined enzymatic activity, i.
MMAC1 was initially located by mapping DNA sequence deletions in glioblastomas.
This increase was primarily due to expanded research activities associated with the Company's collaborations and the post-discovery development of the MMAC1 cancer gene program.
This brain cancer is very aggressive, and our research suggests that mutations in the MMAC1 gene play a role in advancing the aggressiveness of the tumor," said Peter Steck, Ph.
The sequence of the MMAC1 gene provides a number of important clues to its function, a key step in the search for drug targets and eventually for new treatments," said Sean Tavtigian, Ph.
The researchers localized the MMAC1 gene from tumor samples obtained from patients.