ABCC6

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ABCC6

ATP-binding cassette sub-family C (CFTR/MRP) member 6. A gene on 16p13.1 that encodes a protein of the superfamily of ATP-binding cassette (ABC) transporters, which transport various molecules across extra- and intra-cellular membranes.

Significance
The encoded protein is involved in multi-drug resistance; mutations in ABCC6 cause pseudoxanthoma elasticum.
References in periodicals archive ?
In view of the above information, the main aim of the present study was to determine the best algorithm in terms of its predictive performance among CART, CHAID, and ANN types such as RBF, MLP1 and MLP2 in the prediction of BW from selected body measurements in the indigenous Beetal goat of Pakistan.
Finally, the following types of ANN were adopted: RBF networks, MLP1 and MLP2.
As for ANN, the average RBF network had a 7-34-1 structure (the number of neurons in the input, hidden and output layers, respectively), whereas the average MLP1 had a 7-1-1 structure and MLP2 had a 7-13-10-1 structure.
On the other hand, slightly lower values of the Pearson correlation coefficient and the higher values of the errors (RMSE, RAE, and MAPE) and SDratio were found for CART and MLP1.
00 cm had heavier BW, (4) MLP1 and MLP2 had the same importance order of predictors, (5) rump height was the second most significant variable affecting body weight for CHAID, MLP1, MLP2 and MR.
The model MLP1 can be further improved in the following two ways.
Based on the above analysis, the MLP1 can be updated as follows:
The models MLP2 and MLP1 have the same objective function and similar constraints.
The MNLP model is solved using LINGO with a global solver, and the MLP1 and MLP2 models are solved using CPLEX 12.
2) After the incorporation of Constraint (31), the calculation performance of the updated MLP1 and MLP2 models is further improved; that is, the average computation time is decreased to 5-6 seconds.
Secondly, linearization approaches are introduced to transform the MNLP model into MLP1.