IL17F

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IL17F

A gene on chromosome 6p12 that encodes IL-17F, a cytokine which stimulates the production of other cytokines (e.g., IL-6, IL-8 and granulocyte colony-stimulating factor) and regulates cartilage matrix turnover. IL-17F stimulates PBMC and T-cell proliferation and inhibits angiogenesis.
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Other studies that measured the binding of TAK-375 and its major active metabolite to several potential binding sites also showed that it is highly selective for the ML-1 receptor with no affinity for any of several receptors or neurotransmitters including GABA and opiate, peptides, or cytokines.
We are excited about moving forward with the development of TAK-375, due to its high selectivity for the ML-1 receptor, pharmacokinetic profile and low incidence of adverse events," said Dr.
Melatonin, a hormone released by the pineal gland in the brain in response to cycles of light and darkness, is believed to initiate sleep and wake periods by broadly targeting ML-1 receptors.