DUSP1

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DUSP1

A gene on chromosome 5q34 that encodes dual-specificity phosphatase 1, a protein which dephosphorylates MAP kinase MAPK1/ERK2. DUSP1 downregulates cell proliferation and is thought to play a key role in cellular responses to environmental stress. It is also a less preferred gene symbol for what is now designated as DUSP12, see there.
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Conditional expression of mitogen-activated protein kinase phosphatase-1, MKP-1, is cytoprotective against UV-induced apoptosis.
MKP-1 interferes with the inflammatory cascade triggered by LPS, which includes a molecule known as p38, and results in higher levels of IL-6 and TNF-alpha.
Working in laboratory cell lines and mice with specially engineered immune systems, scientists demonstrated that MKP-1 serves as a bridge between the innate immune response that is the body's first line of defense against infection and the more specialized adaptive immune response that follows.
The results raise hopes that the MKP-1 pathway will lead to new tools for shaping the immune response, said Hongbo Chi, Ph.
Scientists found the MKP-1 gene after analysing brain tissue samples from 21 dead patients who were diagnosed with depression.
MKP-1 was found to be twice as active in the brains of those who were depressed, research in the journal Nature Medicine showed.
Scientists identified the gene, called MKP-1, after analysing brain tissue samples from 21 dead patients who were diagnosed with depression.
Aplidin induces JNK-dependent apoptosis in human breast cancer cells via alteration of glutathione homeostasis, Rac and Rho activation, and MKP-1 phosphatase down-regulation.
While Duman's team found several hundred differences, most striking were levels of mRNA for a particular protein, MKP-1, which inhibits a pathway involved in neural growth and development.
Transcriptional induction of MKP-1 in response to stress is associated with histone H3 phosphorylation-acetylation.
Two of MAXIA's new classes of compounds target phosphatases: MX7091 inhibits the phosphatase MKP-1 leading to JUNK activation and apoptosis in vitro and tumor regression in vivo.
Duman's team found that one gene called MKP-1 was increased more than two-fold in the brain tissues of depressed individuals.