MAP2K7

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MAP2K7

A gene on chromosome 19p13.3-p13.2 that encodes a dual-specificity protein kinase that is as an essential component of the MAP kinase signal transduction pathway. With MAP2K4/MKK4, it is the only known kinase to directly activate the SAP/JNKs MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K7 has a specific role in the JNK signal transduction pathway activated by proinflammatory cytokines.
References in periodicals archive ?
Alpinetin suppresses proliferation of human hepatoma cells by the activation of MKK7 and elevates sensitization to cis-diammined dichloridoplatium.
HEK 293 cells were transfected with GAL4-CBP and either empty vector or vectors overexpressing constitutively active MKK1, MKK5, MKK6, or MKK7 mutants that selectively activate ERK1/2, ERK5, p38[alpha], and JNK (respectively).
These polypeptides encode MKK7, including human MKK7 as well as isoforms MKK7b, MKK7c, MKK7d and MKK7e that regulate JNK activity.
In addition, Celgene has issued US patents on p38-beta, MKK3, MKK6, MKK4 and MKK7.