MAP2K6

(redirected from MKK6)

MAP2K6

A gene on chromosome 17q24.3 that encodes a dual-specificity protein kinase that is an essential component of the MAP kinase signal transduction pathway. With MAP3K3/MKK3, MAP2K6 catalyses the phosphorylation of threonine and tyrosine residues in the MAP kinases MAPK11, MAPK12, MAPK13 and MAPK14, and it plays a key role in cellular responses to cytokines and cellular stress. MAP2K3/MKK3 and MAP2K6/MKK6 are both essential for the activation of MAPK11 and MAPK13 induced by environmental stress; MAP2K6/MKK6 mediates apoptotic cell death in thymocytes, regulates melanocyte dendricity by modulating modulation Rho family GTPases, and is the major MAPK11 activator in response to TNF.
References in periodicals archive ?
HEK 293 cells were transfected with GAL4-CBP and either empty vector or vectors overexpressing constitutively active MKK1, MKK5, MKK6, or MKK7 mutants that selectively activate ERK1/2, ERK5, p38[alpha], and JNK (respectively).
We over-expressed either the empty vector or a constitutively active MKK6 mutant in HEK 293 cells, in the presence or absence of o,p'-DDT.
3,19,20) This phosphorylation is regulated by upstream dual-specificity kinases (MAPK kinases, [MAPKKs]) including MKK3, MKK4, and MKK6, which are capable of phosphorylating MAPKs on both serine and threonine as well as on tyrosine residues.
35) MKK6 phosphorylates and strongly activates p38[alpha], p38[beta], and p38[gamma], whereas MKK3 activates p38[alpha] and p38[gamma] but not p38[beta].
These polypeptides are critical reagents for the development of modulators of up-stream kinases such as MKK3, MKK6 and MKK4 that regulate activation of p38 and JNK.
In addition, Celgene has issued US patents on p38-beta, MKK3, MKK6, MKK4 and MKK7.
patent (5,736,381) recently issued for MKK6 and MKK7, two proteins involved in modulating the p38 and JNK gene regulation pathways, as well as JIP-1, another JNK regulatory protein.