MITF


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MITF

Microphthalmia transcription factor. A helix-loop-helix leucine zipper-type transcription factor encoded by MITF on chromosome 3p14.2-p14.1, which is involved in melanocyte and osteoclast development. MITF controls the DNA damage response, and plays a critical role in melanoma proliferation; its inhibition is associated with G0-G1 growth arrest, and lineage-specific senescence in melanomas.
References in periodicals archive ?
Together, in the dermal skin of the HRM-2 hairless mice, MHY498 reduced UVB-induced skin pigmentation by suppressing melanogenesis at least partially through decreases in CREB phosphorylation and MITF translocation to nucleus.
But MITF also makes stem cells turn into melanocytes in the first place and controls cell proliferation and death in these cells.
of Ophthalmology and Visual Science, University of Wisconsin School of Medicine and Public Health, Madison, WI for "The Role of MITF in Early Retinal Fate Determination in Human Embryonic Stem Cells"; Alecia Gross, Assistant Professor, Dept.
Immunohistochemically, tumor cells are consistently positive for S100 (Figure 14, B), SOX10, and vimentin, but negative for melanocytic markers HMB-45, Melan-A, tyrosinase, and MITF (microphthalmia transcription factor).
MITF mutations associated with a dominant white phenotype were not found in Hanwoo.
Expression of MITF increases melanin production by facilitating biosynthesis of tyrosinase, tyrosinase-related protein 1 (TRP-1), and TRP-2 [31].
Immunoprofile of MITF, tyrosinase, melan-A, and MAGE-1 in HMB45-negative melanomas.
Immunohistochemistry with S- 100 protein, HMB-45, Melan-A, PNL2, and MITF can aid in making a definitive diagnosis of mucosal melanoma.
The identified mutation occurs in the gene encoding MITF, a transcription factor that induces the production of several important proteins in melanocytes, the cells in which melanoma originates.
Han sido descritos en el gen MITF 9 promotores diferentes, cada uno de los cuales codifica una isoforma con extremo 5' unico, aunque tienen en comun los exones 2 al 9 que codifican para los dominios funcionales de los factores de transcripcion.
Recently, MITF has been shown to be a novel melanoma survival oncogene and this protein may play a potentially important role in the development and progression of melanoma in humans.
Afterwards, MITF activates the transcription of tyrosinase, which catalyzes the first step of melanogenesis (Smyth, 1990; Scherer and Kumar, 2010).