MITF


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MITF

Microphthalmia transcription factor. A helix-loop-helix leucine zipper-type transcription factor encoded by MITF on chromosome 3p14.2-p14.1, which is involved in melanocyte and osteoclast development. MITF controls the DNA damage response, and plays a critical role in melanoma proliferation; its inhibition is associated with G0-G1 growth arrest, and lineage-specific senescence in melanomas.
References in periodicals archive ?
Mutations of the MITF gene that have been described in several vertebrate species lead to coat colour dilutions, white spotting, or complete loss of pigmentation in mouse (Hodgkinson et al.
But MITF also makes stem cells turn into melanocytes in the first place and controls cell proliferation and death in these cells.
In contrast, the activation of ERK reduces melanin synthesis by downregulating MITF expression (Kim et al.
The changes of microRNA expression profiles and tyrosinase related proteins in MITF knocked down melanocytes.
While previous research has suggested that MITF may act as a melanoma oncogene, the current study by researchers from the U.
MITF transcriptional regulates the expression of tyrosinase and tyrosinase-related protein that control the conversion of tyrosine to melanin pigments (Vachtenheim and Borovansky 2010).
One such regulator, called MITF, controls an array of genes that influence melanocyte development, function and survival.
Cells were then incubated in presence of following primary antibodies for 60 min at 37[degrees]C at dilutions indicated: i) polyclonal rabbit anti S-100 antigen IgG (Zhongshan Biotechnological Ltd Co, Guangzhou, China) at 1:400 dilution; ii) monoclonal mouse anti human tyrosinase (Santa Cruz Biotechnology, Santa Cruz, CA USA) at 1:75 dilution and iii) mouse monoclonal anti human MITF (Neomarkers, Fremont, CA, USA) at 1:75 dilution.
a leading medical diagnostics/research company specializing in the development of monoclonal antibodies and diagnostic assays for cancer, infectious disease, and neurodegenerative disease, today announced the availability of Cyclin D1, MITF, and PCNA.
John Nolan has been a special leader, a true partner, and the results he's enabled us to achieve have been presented here every year," said MITF co- chair Michael J.
Representatives of the MITF, a public/private partnership between the U.
Immunoprofile of MITF, tyrosinase, melan-A and MAGE-1 in HMB-45 negative melanomas.