CADASIL(redirected from MIM 125310)
CADASILCerebral autosomal dominant arteriopathy with subcortical infarcts & leukoencephalopathy. An autosomal dominant neurologic disorder of adult onset caused by mutations in NOTCH3, which maps to chromosome 19q12.
Migraine, recurrent strokes, progressive dementia.
MRI—anterior temporal pole involvement, skin biopsy with anti-NOTCH3 antibody.