Imaging with CT or MRI of the abdomen localizes the tumor; MIBG
scanning may not always be needed.
calcifications; CSI-OP = chemical shift imaging, opposed phase; GRE = gradient echo sequence; IVC = inferior vena cava; MIBG
= m-iodobenzylguanidine; RPW = relative percentage washout; VMA = vanillylmandelic acid.
therapy is an option for tumours that are proven to be MIBG
While traditional I-131 MIBG
has demonstrated clinical activity in neuroblastoma in the past, it contains cold contaminants that compete with the active radiotherapeutic molecules binding to receptor sites on tumor cells.
Preoperative imaging should be maximized to include MRI and MIBG
, as well as possible evaluation of arterial supply to the lesion and venous drainage with MR-angiography.
The most important potential use for MIBG
may be as a means to assess coronary artery disease and heart failure.
Additional staging of disease may include a combination of diagnostic imaging tests, such as chest x-ray, abdominal ultrasound, computerized tomography (CT), magnetic resonance imaging (MRI), MIBG
scan and bone scan.
On this basis, I-131 MIBG
is sensitive and specific for detecting localised and metastatic neuroblastoma, phaeochromocytoma, paraganglioma and medullary thyroid carcinoma.
Total body octreotide scans can also be used in the metastastic work-up (5) and most recently radionucleotide scanning such as MIBG
scintiscan is playing an important role.
CT and MIBG
scans costing more than pounds 3,000 have shown that Connah's main stomach tumour has calcified - meaning that it has died in the centre.
uptake inferomedial to the right hepatic lobe at the location of the right adrenal gland.
scans are used specifically for pheochromocytomas or any tissues that take up MIBG
in the adrenergic vesicles in the adrenal medulla.