Imaging with CT or MRI of the abdomen localizes the tumor; MIBG
scanning may not always be needed.
Spearman correlation coefficients were used to examine the relationships between disease duration, modified Hoehn and Yahr score, or L-dopa equivalent daily dose and the results of MIBG
myocardial scintigraphy and autonomic function tests.
calcifications; CSI-OP = chemical shift imaging, opposed phase; GRE = gradient echo sequence; IVC = inferior vena cava; MIBG
= m-iodobenzylguanidine; RPW = relative percentage washout; VMA = vanillylmandelic acid.
imaging is reserved for situations where the tumours are thought to be of enterochromaffin origin.
31) Severe cholinergic deafferentation of the neocortex, particularly in posterior cortical regions (32) Single photon emission computed tomography Parietotemporal hypoperfusion Occipital hypoperfusion 123I-FP-CIT SPECT (DaT scan) No significant loss of DaT Low nigrostriatal terminal density of DaT caused by severe nigrostriatal degeneration (16) Myocardial scintigraphy with MIBG
No significant change in MIBG
uptake (33) uptake 123I-FP-CIT: 123I-2[beta]-carbomethoxy-3[beta]-(4-iodophenyl)-N- (3-fluoropropyl)nortropane; DaT: dopamine transporter; FDG PET: [18F]-fluoro-d-glucose positron emission tomography; MIBG
: metaiodobenzylguanidine; SPECT: single photon emission computed tomography
and PET are negative, somatostatin receptor scintigraphy (octreoscan) may be of help.
Back in September the Daily Post revealed that CT scans and MIBG
scans overseas showed his main stomach tumour had calcified - meaning it has died in the centre.
Over 20 medicines may potentially interfere with MIBG
biodistribution, sometimes many hours after they have been taken.
Azedra is a targeted radiotherapeutic comprised of the known I-131 MIBG
molecule radiolabeled using Molecular Insight's proprietary Ultratrace technology, which removes unnecessary nonradioactive molecules, or cold contaminants, to maximize therapeutic potential.
An OctreoScan was performed instead of a MIBG
scan to evaluate for metastatic or synchronous lesions, since the patient was allergic to iodide.
(iodine-131-meta-iodobenzylguanidine) nuclear medicine scan demonstrated two large foci of tracer uptake, one on either side of the abdominal midline, highly suggestive of phaeochromocytomas.
CT scan will show a hypervascular lesion, MRI will show a lesion with high intensity on T2 weighted imaging, and 123I MIBG
will usually show intense uptake.