ROR2

(redirected from MGC163394)

ROR2

A gene on chromosome 9q22 that encodes a tyrosine kinase and type-I transmembrane protein belonging to the ROR subfamily of cell surface receptors, which may play a role in early chondrocyte formation, and may be required for cartilage and growth plate development.

Molecular pathology
ROR2 mutations cause brachydactyly type B and the autosomal recessive form of Robinow syndrome, which is characterised by skeletal dysplasia with shortening of long bones, segmental defects of the spine, brachydactyly and facial dysmorphia.