FGA

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FGA

A gene on chromosome 4q28 that encodes the alpha chain of a fibrinogen, a heterotrimeric glycoprotein which is cleaved by thrombin to form fibrin, the most abundant component of blood clot.

Molecular pathology
FGA  mutations are linked to afibrinogenaemia (which is universally fatal in infancy), hypofibrinogenaemia, dysfibrinogenaemia and renal amyloidosis.