TGFBR2

(redirected from MFS2)

TGFBR2

A gene on chromosome 3p22 that encodes a transmembrane kinase of the TGFB receptor subfamily of Ser/Thr protein kinases, which forms a heteromer with type-I TGF-beta receptors and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which enter the nucleus and regulate transcription of cell proliferation-related genes.

Molecular pathology
TGFBR2 mutations are associated with Marfan syndrome, Loeys-Deitz aortic aneurysm syndrome and development of various tumours.
References in periodicals archive ?
As a collective the MHA estimates (but does not guarantee or warrant) a total spend of approximately 250 000 000 GBP (Based on spend put through the MFS2 framework agreement a predecessor of MSF3) on the delivery of highways schemes during the lifetime of the framework agreement.