Also found in: Dictionary, Thesaurus, Legal, Financial, Acronyms, Encyclopedia, Wikipedia.


A gene on chromosome 20p13 that encodes a ubiquitous immunoglobulin-like cell surface receptor for CD47 that acts as a docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. SIRPA supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment, and may play a key role in intracellular signalling during synaptogenesis and in synaptic function. It downregulates receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors and insulin; it also downregulates phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. It is highly expressed in the brain.


1. A document that, if signed by the patient or the patient's legal representative, permits the treating health care provider to perform certain procedures. In addition to being signed by the patient, the release should also be signed by a witness. Most releases have a notation indicating the applicable time of the release.
2. To discharge.
3. To remove restraints.

extended release

In pharmacology, the slow or gradual absorption of a drug after ingestion, e.g., one that achieves a peak concentration in the blood after about 6 hr.

immediate release

In pharmacology, the rapid absorption of a drug after ingestion.

myofascial release

Abbreviation: MFR
The manipulation of soft tissue to facilitate improved posture and range of motion and to decrease pain.
See: soft-tissue mobilization

surgical release

Freeing tissues or organs trapped in place by adhesions or scars.

sustained release

The delivery of a drug from a tablet or other reservoir over many hours or days (instead of minutes or hours), to provide a durable therapeutic effect.

myofascial release

Abbreviation: MFR
The manipulation of soft tissue to facilitate improved posture and range of motion and to decrease pain.
See: soft-tissue mobilization
See also: release


References in periodicals archive ?
At the extremes, commercial raw materials can be found with MFR as low as 0.
The actual MFR value certainly has implications for processing.
When we sampled a grade with a nominal MFR of 10 g/10 min we did, in fact, observe that we could reduce the melt temperature of the material by 40[degrees]F (22[degrees]C), and our pressure during first-stage filling declined by 10%.
Short chains flow more easily than long ones, and the MFR will display a corresponding increase.
The Series 7000 provides a complete high-performance Frame Relay service aggregation and switching solution for both MFR and any combination of DS-0, NxDS-0, and T1 Frame Relay service.
Larscom's new iPLEX 6000 is the industry's first Frame- and IP-aware multilink access solution to support the new MFR specification.
15), MFR allows the use of multiple transmission facilities - multiple 56/64K, multiple T1, or multiple ISDN B Channels - to be aggregated and treated as a single logical frame relay stream.
MFR Capital Partners is a New York City-based merchant banking firm specializing in global communications and connectivity opportunities.
Department of Justice has been challenging the use of MFRs in the health insurance industry in Ohio and elsewhere for several years.
is pleased to announce the launch of its first in a new series of no-load funds to be developed in a joint venture between Lexington and MFR Advisors Inc.
The 5 MFR material is aimed at dialysis parts, stopcocks, luers, and other intricate devices.
Gordon Sharp, a director at KPMG Pensions, said: "The MFR has proved to be a bureaucratic system which did not meet its supposed intention of providing security for pension scheme members.