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A gene on chromosome 20p13 that encodes a ubiquitous immunoglobulin-like cell surface receptor for CD47 that acts as a docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. SIRPA supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment, and may play a key role in intracellular signalling during synaptogenesis and in synaptic function. It downregulates receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors and insulin; it also downregulates phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. It is highly expressed in the brain.


1. A document that, if signed by the patient or the patient's legal representative, permits the treating health care provider to perform certain procedures. In addition to being signed by the patient, the release should also be signed by a witness. Most releases have a notation indicating the applicable time of the release.
2. To discharge.
3. To remove restraints.

extended release

In pharmacology, the slow or gradual absorption of a drug after ingestion, e.g., one that achieves a peak concentration in the blood after about 6 hr.

immediate release

In pharmacology, the rapid absorption of a drug after ingestion.

myofascial release

Abbreviation: MFR
The manipulation of soft tissue to facilitate improved posture and range of motion and to decrease pain.
See: soft-tissue mobilization

surgical release

Freeing tissues or organs trapped in place by adhesions or scars.

sustained release

The delivery of a drug from a tablet or other reservoir over many hours or days (instead of minutes or hours), to provide a durable therapeutic effect.

myofascial release

Abbreviation: MFR
The manipulation of soft tissue to facilitate improved posture and range of motion and to decrease pain.
See: soft-tissue mobilization
See also: release


References in periodicals archive ?
I have had the experience of working with material suppliers to narrow a MFR specification range to improve the consistency of molded part performance.
Next month we will explore the reasons for the perception of MFR as a barrier to processing and explain why processes that exhibit sensitivity to lot-to-lot fluctuations in MFR have fundamental problems related to the molding machine or the way the process is set up.
In the next article we will explore the quantitative relationship between MFR and MW, the utility of using low shear rates to measure MW, and the reasons why some processors are convinced that variations in their process are caused by lot-to-lot variation in the MFR of the material.
In our next article we will describe the MFR test procedure and discuss some of the strengths and weaknesses of the test.
And this reduction in fiber length will cause an increase in MFR that is independent of changes in the molecular weight of the polymer.
5 MFR material with a flexural modulus of 300,000 psi aimed at sporting goods, automotive components, RV parts, canoes, kayaks, all-terrain vehicles, and tractors.
Tiara's new standards-based MFR product solutions supercharge Service Providers' Frame Relay infrastructure to fill the bandwidth gap between T1 and the next step up in network access technology, fiber-based T3," commented Kash Mitra, vice president of marketing at Tiara.
Both MFR and IMA 'bridge the bandwidth gap' between T1/E1 and T3/E3 service delivery, making such service offerings as high speed Internet access and integrated voice/data an affordable reality for both service provider and end customer.
Prior to MFR functionality, a basic ISDN PRI link could offer dial backup support for up to 23 individual remote sites at 64 Kbps bandwidth for each site.
OTC BB:SINC) and Sun Technology Solutions, LLC ("Sun") announced today that Sun has the direct support of MFR Capital Partners, LLC ("MFR") for Sun's involvement in the Southland fiber optic network project in Hong Kong.
Under the terms of the 60-month, section 845 cost plus award fee contract, Raytheon will develop the MFR prototype radar and qualify it through operational tests.
The 12-melt MFR grade, HP 84491, has 195 kpsi flexural modulus and a 1.