MFN1

MFN1

A gene on chromosome 3q26.33 that encodes mitofusin 1, an essential transmembrane GTPase that mediates mitochondrial fusion, an important step in mitochondria morphology which is balanced between fusion and fission. MFN1 acts independently of the cytoskeleton. It is expressed in the kidney and heart; some isoforms may be overexpressed in tumours, including lung cancer.
References in periodicals archive ?
On the other hand, another group examined the protein levels of hFis1, Drp1, and MFN2 in HeLa cells in which MARCH5 had been knocked down and found that there was no change in these proteins, but there was an increase in MFN1 protein levels.
MFN1 contains a putative cyclin B1 phosphorylation site and interacts with cyclin B1 in asynchronously dividing cells.
To date work on MARCH5 indicates that it regulates the morphology of the mitochondria through its regulation of MFN1, MFN2, Drp1, and hFis1 [38, 39, 69-71].
Both human and mouse cells have two proteins, called MFN1 and MFN2, which control outer membrane fusion.
MFN1 and MFN2 are found in different amounts in different body organs.