METAVIR scoring system

METAVIR scoring system

A system used to assess inflammation and fibrosis by histopathological evaluation of a liver biopsy of patients with hepatitis C. The grade indicates the activity or degree of inflammation, and the stage represents the amount of fibrosis or scarring.

Activity grade
• A0—No activity.
• A1—Mild activity.
• A2—Moderate activity.
• A3—Severe activity.
Fibrosis stage
• F0—No fibrosis.
• F1—Portal fibrosis without septa.
• F2—Portal fibrosis with few septa.
• F3—Numerous septa without cirrhosis.
• F4—Cirrhosis.
References in periodicals archive ?
Liver biopsies were analyzed for the fibrosis stage in each center by the local pathologist, using the METAVIR scoring system.
The integrated database included published prospective studies of chronic hepatitis C patients with concomitant FT measurement and liver biopsy, who had liver biopsies scored using the METAVIR scoring system (5), had FT assessed on fresh serum using the recommended preanalytical and analytical procedures, and had individual data sent by the principal investigator.
Studies were included if fibrosis had been evaluated using the METAVIR scoring system, the diagnostic value was expressed using the AUC and the prevalence of different fibrosis stages was given.
A pathologist who was unaware of the biochemical markers evaluated the fibrosis stage and necrosis grade according to the METAVIR scoring system (5).
First there is a controversy concerning the linear association between the METAVIR scoring system and the quantity of fibrosis, and also concerning the linear progression of fibrosis.
who was unaware of the results for the biochemical markers, evaluated the stage of fibrosis and grade of activity according to the METAVIR scoring system (20, 21).
00, corresponding to stages FO-F4 and grades A0-A3 of the well-established METAVIR scoring system.
The definition of a significant discordance between FT-AT and biopsy results was a discordance of at least two stages or two grades in the METAVIR scoring system.