MEST


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MEST

Mixed Epithelial Stromal Tumour. A usually benign renal lesion characterised by epithelial lined tubular or cystic structures interspersed within a variably prominent, distinctive spindle-cell stroma.
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Although focal progesterone receptor expression has been described in malignant MEST, all cases of malignant MEST are negative for estrogen receptor expression.
A recent case report showed an MEST that has translocation t(1;19).
The female preponderance of MEST and history of long-term estrogen replacement in female patients or long-term sex-steroid exposure in male patients, combined with the frequent expression of estrogen and progesterone receptors in the mesenchymal component, suggest that the steroid hormones might play a role in the evolution of these tumors.
There are striking similarities between CN and MEST in their clinical behavior, morphologic attributes of both the epithelial and stromal components, and immunohistochemical profiles although with variation in individual categories with higher prevalence of stromal to epithelial ratio, prominent ovarian stroma, smaller cysts with phyllodes glands pattern, and stromal luteinization being more prominent in MEST, and large cysts, thin septa, and low stromal to epithelial ratio in CN.
7] Human genes: MEST, mesoderm specific transcript homolog (mouse); H19, H19, imprinted maternally expressed transcript; KCNQ1OT1, KCNQ1 overlapping transcript 1; GRB10, growth factor receptor-bound protein 10; IGF2, insulin-like growth factor 2 (somatomedin A).
In phase 2, the incubator stage, the MEST entrepreneurs get seed funding and incorporate their companies.
In phase 3, the MEST entrepreneur's primary focus is commercial deployment and scaling of their business.
The progression of so many companies to the MEST Incubator stage is a testament to the entrepreneurial spirit of our students, and the remarkable business ideas that they've developed," said Jorn Lyseggen, CEO and founder of Meltwater.
Founded in 2008, MEST aims to provide its students with the skills required to establish software companies in the global marketplace and thereby creating jobs and wealth locally in Africa.
MEST is set to run until tomorrow with over 20 exhibitors displaying stands and conferences featuring case studies running from 9am to 5pm.