MEN2


Also found in: Acronyms.

MEN2

MEN2

Abbreviation for multiple endocrine neoplasia 2.
References in periodicals archive ?
A cysteine radical mutation (C620R and C620W) was related to MEN2 in 3 families, with proven MTC in recurrent patients in 2 and suspected in the other.
This study confirms the association of RET gene mutation with cancer risk in MEN2 and MTC families in all ethnic groups in the diverse South African population.
21) Consistent associations exist between RET genotype and phenotype, and the 'gain of function' variations associated with MEN2 can be divided into two main groups (viz.
Genetic screening is extremely sensitive in MEN2 syndromes, and children of MTC families who are carriers of mutant genes are at risk and may be identified by detection of the germline mutation in the RET proto-oncogene.
A further interesting phenomenon is the relatively uncommon co-segregation of HSCR and MEN2 in the same patient, (20,29,30) i.
RET gene mutation carries a risk of MEN2 and MTC in all ethnic groups in South Africa.
The most efficient testing strategy for some of the less complex MEN2 mutations (codons 768-918) have involved techniques such as restriction fragment length polymorphism analysis or a fluorescence resonance energy transfer/hybridization probe-based method (10).
Because of the various types of mutations observed with MEN2, a single DNA diagnostic method that is simple, inexpensive, and efficient for the detection of all predominant mutations would be of great use.
In accordance with Institutional Review Board guidelines, archived samples previously referred to the Mayo Clinic Molecular Genetics laboratory for MEN2 testing were selected for study inclusion.
Currently, one of the most reliable molecular assays for the diagnosis of MEN2 is DNA sequencing.
In this study, we evaluated several pyrosequencing-based assays designed to interrogate a series of both simple and complex common mutations associated with MEN2 and evaluated their performance characteristics.
The sensitivity problem may be more relevant for HSCR, where mutations are distributed throughout the coding sequence [8], than for MEN2, where mutations are found in only a few exons.