MEN1


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MEN1

MEN1

Abbreviation for multiple endocrine neoplasia 1.
References in periodicals archive ?
Who Should Consider MEN1 Screening by Gene Testing?
Screening may be offered to persons with MEN1 or FMEN1 or with features resembling them.
MEN1 screening by gene testing will be the most definitive test, when it is available.
A person who has FMEN1 or who has a positive MEN1 gene mutation may have a hard time deciding whether to have a child.
We were interested in confirming the role of MEN1 mutations in sporadic gastrinomas and in determining if mutations in the MEN1 gene could be identified in DNA extracted from paraffin-embedded gastrointestinal neuroendocrine tumors.
Tumor DNA was compared with that of a control patient without MEN1.
A semiquantitative technique was used in an attempt to determine the number of MEN1 alleles present in comparison to the number of alleles of the CFTR gene.
Nine tumor specimens, including six gastrinomas and three nonfunctioning neuroendocrine tumors, were evaluated for MEN1 mutations, using the technique of heteroduplex analysis.
121 The second study also included 46 PENs that were analyzed for 11 genes, 7 of which were common to both reports and showed the following methylation rates: RASSF1A (80%), P16/INK4A (0%), MGMT (17%), MLH1 (0%), APC (48%), E-cadherin (2%), TIMP3 (0%); the remaining 4 genes were MEN1 (19%), HIC-1 (93%), RUNX3 (7%), and PTEN (0%).
To date, mutation of MEN1 and allelic loss of chromosome 11q, which encompasses the region containing the MEN1 locus, are the most common genetic alterations found in PENs.
In contrast to the low rate of MEN1 mutations, more than 50% of all PENs exhibit losses at 11q13 and/or more distal parts of the long arm of chromosome 11.