MEN 2B


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MEN 2B

An inherited neoplasia syndrome characterised by medullary thyroid carcinoma, phaeochromocytoma, mucocutaneous ganglioneuromas and a marfinoid habitus.

Molecular pathology
A single amino acid change is present in RET oncogene (met918thr) on chromosome 10.
References in periodicals archive ?
5) A primary criteria for differentiation of MEN 2B from MEN 2A is the absence of mucosal neuromas in the latter.
11) Although intestinal neuromas causing obstruction usually precede the diagnosis of extra-intestinal endocrine manifestations, our report presents a unique case of a colonic mucosal neuroma causing obstruction in a patient with MEN 2B syndrome 4 years after the diagnosis of medullary thyroid carcinoma.
All of the patients had inherited MTC (MEN 2A, MEN 2B, or FMTC) and had known genomic RET mutations previously analyzed by sequence analysis (by S.
The single known exon 16 mutation associated with MEN 2B and sporadic MTC was identified by the Phastgel system at an electrophoretic temperature of 4[degrees]C (Fig.