MEN 2B


Also found in: Acronyms.

MEN 2B

An inherited neoplasia syndrome characterised by medullary thyroid carcinoma, phaeochromocytoma, mucocutaneous ganglioneuromas and a marfinoid habitus.

Molecular pathology
A single amino acid change is present in RET oncogene (met918thr) on chromosome 10.
References in periodicals archive ?
The hallmark of MEN 2B syndrome is the presence of characteristic mucosal neuromas on the distal portion of the tongue, lips, subconjunctival areas, and throughout the gastrointestinal tract.
5) A primary criteria for differentiation of MEN 2B from MEN 2A is the absence of mucosal neuromas in the latter.
All of the patients had inherited MTC (MEN 2A, MEN 2B, or FMTC) and had known genomic RET mutations previously analyzed by sequence analysis (by S.