MEN 2A


Also found in: Acronyms.

MEN 2A

An inherited neoplasia syndrome characterised by medullary thyroid carcinoma (100%), phaeochromocytoma (50%) and parathyroid hyperplasia (10–20%).

Molecular pathology
Mutation of RET on chromosome 10.
References in periodicals archive ?
Mutations in the RET proto-oncogene are associated with MEN 2A and FMTC.
Cys634 mutations in the RET proto-oncogene in Spanish families affected by MEN 2A.
High prevalence of the C634Y mutation in the RET protooncogene in MEN 2A families in Spain.
Josep Oriola (Hospital Clinic, Barcelona, Spain) for providing us with DNA samples from patients affected with MEN 2A and to Dr.
Specific mutations of the RET proto-oncogene are related to disease phenotype in MEN 2A and FMTC.
Molecular screening for RET proto-oncogene mutations in a German MEN 2A pedigree.
6) Nonstandard abbreviations: MEN 2A, multiple endocrine neoplasia type 2A; MEN 213, multiple endocrine neoplasia type 213; FMTC, familial medullary thyroid carcinoma; PCR, polymerase chain reaction; SSCP, single-strand conformation polymorphism; and MTC, medullary thyroid carcinoma.