MEN 2A


Also found in: Acronyms.

MEN 2A

An inherited neoplasia syndrome characterised by medullary thyroid carcinoma (100%), phaeochromocytoma (50%) and parathyroid hyperplasia (10–20%).

Molecular pathology
Mutation of RET on chromosome 10.
References in periodicals archive ?
At present, no single-step method exists to carry out a molecular analysis of the hotspots related to MEN 2A and FMTC that can be applied to routine diagnosis.
Cys634 mutations in the RET proto-oncogene in Spanish families affected by MEN 2A.
High prevalence of the C634Y mutation in the RET protooncogene in MEN 2A families in Spain.
We think it is useful in the screening of RET for the most common mutation in MEN 2A and especially to establish the carrier status in members of families with MEN 2A and FMTC already characterized as having the 634 mutation.
Josep Oriola (Hospital Clinic, Barcelona, Spain) for providing us with DNA samples from patients affected with MEN 2A and to Dr.
4), exon 11 would be screened initially for mutations at an electrophoretic temperature of 10[degrees]C, given that 87% of the mutations associated with MEN 2A involve codon 634 in exon 11 [16].
Molecular screening for RET proto-oncogene mutations in a German MEN 2A pedigree.