MAP3K3

(redirected from MEKK3)

MAP3K3

A gene on chromosome 17q23.3 that encodes a MAPK kinase kinase belonging to a protein kinase signal transduction cascade. MAP3K3 activates NF-kappaB, AP1 and DDIT3 transcription regulators.

Each mitogen-activated protein kinase (MAPK) pathway is a conserved cascade of three protein kinases: an activated MAPK kinase kinase (MAPKKK) phosphorylates and activates a specific MAPK kinase (MAPKK), which in turn activates a specific MAPK.
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Insulin-like growth factor-1 enhances inflammatory responses in endothelial cells: role of Gab1 and MEKK3 in TNF-[alpha]-induced c-Jun and NF-[kappa]B activation and adhesion molecule expression," Circulation Research, vol.
Insulin-like growth factor-1 enhances inflammatory responses in endothelial cells: role of Gab1 and MEKK3 in TNF-a'-induced c-Jun and NF-B activation and adhesion molecule expression.
The ubiquitination of IKK[gamma]/NEMO may lead to the recruitment of an I-[kappa]B[beta] kinase, such as MEKK3 or [zeta]PKC to the IKK complex, thereby resulting in I-[kappa]BP phosphorylation and consequently IKK activation.
The essential role of MEKK3 in TNF-induced NF-kappa B activation.
PA28gamma is an anti-apoptotic factor as it is an endogenous substrate for MEKK3, caspase-3 and caspase-7 (Barton et al.
MEKK3 interacts with the PA28 gamma regulatory subunit of the proteasome.
The MAPKKK in JNK pathway includes MEKK1, MEKK2, MEKK3, and MEKK4, MLK, and ASK1 and MAPKK contain MKK4, MKK3, MKK6, and MKK7 [62, 63].
Oxidative stress directly or indirectly affects ASK1, MEKK1, MEKK2, MEKK3, MEKK4, and MLK3 and subsequently activates p38 pathway (Figure 3).